MediLens Intelligence
Features

醫學研究趨勢

AI精選本週最具影響力的29個專科論文

最後更新: 2026年4月1日

心臟病學5

影響力 3

Evolving Strategies in Cardiac Amyloidosis: From Mechanistic Discoveries to Diagnostic and Therapeutic Advances.

發表日期: 2026-04-01

Heart failure clinics

MediLens 收錄日: 2026-04-02

The diagnosis and treatment of cardiac amyloidosis have significantly progressed over the last decade, focusing on the pathogenesis of the disease. Noninvasive imaging has enhanced the diagnosis of ATTR cardiomyopathy, while novel treatments, including protein stabilizers and gene editing, have e...

在PubMed上閱讀
影響力 3

Surgical Site Infection in Coronary Artery Bypass: Observational Study.

發表日期: 2026-04-01

International journal of nursing practice

MediLens 收錄日: 2026-04-02

This observational study assessed adherence to surgical site infection prevention measures in patients undergoing coronary artery bypass grafting at a university hospital. The mean adherence score was 71.18%, but the infection rate was notably high at 55.8%, with some infections leading to hospit...

在PubMed上閱讀
影響力 3

Bundled Care Interventions for the Management of Intracerebral Hemorrhage: A Review.

發表日期: 2026-04-01

Critical care nurse

MediLens 收錄日: 2026-04-02

The management of spontaneous intracerebral hemorrhage is critical due to its significant impact on disability and mortality. The 2024 American Heart Association/American Stroke Association guidelines recommend bundled care interventions, including blood pressure control and anticoagulation rever...

在PubMed上閱讀
影響力 3

Association of insomnia and its proteomic signatures with incident heart failure: A European population-based study.

發表日期: 2026-04-01

Sleep health

MediLens 收錄日: 2026-04-02

This study investigates the association between insomnia and heart failure using data from 52,273 participants in the UK Biobank. It finds that insomnia is independently linked to an increased risk of heart failure (HR: 1.39; 95% CI: 1.17-1.65) and identifies 118 proteins related to insomnia that...

在PubMed上閱讀
影響力 2

Decreased AMP-kinase function in pulmonary artery smooth muscle cells contributes to pulmonary artery remodeling in persistent pulmonary hypertension of the newborn.

發表日期: 2026-04-01

American journal of physiology. Lung cellular and molecular physiology

MediLens 收錄日: 2026-04-02

This study investigates the role of decreased AMPK function in pulmonary artery smooth muscle cells (PASMCs) in the context of persistent pulmonary hypertension of the newborn (PPHN). Using fetal lambs, the research reveals that PPHN is associated with decreased levels of phosphorylated AMPK, PGC...

在PubMed上閱讀

腫瘤科1

影響力 1

Bridging mechanism and clinic: unlocking the full potential of oncolytic virus-based immunotherapy.

發表日期: 2026-03-31

Molecular cancer

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

神經內科1

影響力 1

Retraction Note: An intelligent learning system based on electronic health records for unbiased stroke prediction.

發表日期: 2026-03-31

Scientific reports

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

消化內科5

影響力 3

Bifunctional nanoparticles based on esterified hydroxypropyl β-cyclodextrin/quaternary ammonium chitosan for ulcerative colitis intervention.

發表日期: 2026-04-01

Food research international (Ottawa, Ont.)

MediLens 收錄日: 2026-04-02

This study presents a novel approach to ulcerative colitis therapy using oral nanoparticles that combine anti-inflammatory effects with gut microbiome modulation. The nanoparticles, developed through self-assembly, utilize curcumin for its anti-inflammatory properties and anthocyanin for microbio...

在PubMed上閱讀
影響力 3

Exploration of a Model for Elimination of Hepatitis C in Women of Childbearing Age in Primary Hospitals in Southern China.

發表日期: 2026-04-01

Journal of viral hepatitis

MediLens 收錄日: 2026-04-02

This study evaluated an intervention model for Hepatitis C virus (HCV) elimination in women of childbearing age, focusing on 'treatment as prevention'. Launched in October 2022, the project enhanced HCV-Ab screening, RNA testing, and treatment referrals through multidisciplinary collaborations. K...

在PubMed上閱讀
影響力 3

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study.

發表日期: 2026-04-01

Liver international : official journal of the International Association for the Study of the Liver

MediLens 收錄日: 2026-04-02

This study analyzed outcomes in 571 patients who underwent liver transplantation for primary sclerosing cholangitis (PSC) in France from 1985 to 2019. The median follow-up was 89 months, with patient survival rates at 5, 10, and 20 years being 88.2%, 81.2%, and 62.6%, respectively. Graft survival...

在PubMed上閱讀
影響力 3

Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2.

發表日期: 2026-04-01

Chemical biology & drug design

MediLens 收錄日: 2026-04-02

This study investigates the cytotoxic effects of sulfonated silver(I) and gold(I) N-heterocyclic carbene complexes on human liver cancer cells. The results indicate that these complexes induce autophagic cell death rather than apoptosis, characterized by increased expression of autophagy markers ...

在PubMed上閱讀
影響力 3

Phytogalactolipids triggered oxidative stress to inhibit drug-resistant colorectal cancer by suppressing interferon-α-induced protein 6.

發表日期: 2026-04-01

Phytomedicine : international journal of phytotherapy and phytopharmacology

MediLens 收錄日: 2026-04-02

This study investigates the pharmacological mechanism and therapeutic efficacy of galactolipids from Crassocephalum rabens (CRA) for treating drug-resistant colorectal cancer (CRC). CRA demonstrated antitumor activity by inducing ROS-mediated cytotoxicity through the inhibition of IFI6 expression...

在PubMed上閱讀

呼吸內科5

影響力 3

Upfront treatment with osimertinib in lung cancer patients with and without active brain metastases, and the role of ctDNA as a biomarker; a phase II clinical trial (the FIOL study).

發表日期: 2026-04-01

Lung cancer (Amsterdam, Netherlands)

MediLens 收錄日: 2026-04-02

This phase II trial evaluated the efficacy of osimertinib in patients with EGFR-mutated non-small cell lung cancer, focusing on those with untreated brain metastases. The study included 100 patients, showing an overall objective response rate of 72.0%, with 81.8% in those with measurable brain me...

在PubMed上閱讀
影響力 3

Overall survival for amivantamab plus lazertinib versus osimertinib as first-line treatment in Asian participants with EGFR-mutant advanced NSCLC: A MARIPOSA subset analysis.

發表日期: 2026-04-01

Lung cancer (Amsterdam, Netherlands)

MediLens 收錄日: 2026-04-02

The study evaluated the overall survival (OS) of amivantamab-lazertinib compared to osimertinib in Asian patients with untreated EGFR-mutated advanced non-small cell lung cancer (NSCLC). Results showed a significant improvement in OS for amivantamab-lazertinib, with a hazard ratio of 0.74 at a me...

在PubMed上閱讀
影響力 3

Defining response-adapted surgery after neoadjuvant systemic therapy in sinonasal squamous cell carcinoma.

發表日期: 2026-04-01

Oral oncology

MediLens 收錄日: 2026-04-02

This study presents a novel classification system for documenting surgical outcomes in patients with sinonasal squamous cell carcinoma (SCC) undergoing neoadjuvant therapy. The framework addresses the complexities of sinonasal anatomy and aims to standardize the evaluation of surgical morbidity a...

在PubMed上閱讀
影響力 3

Xbp1-driven lipid metabolism promotes immunosuppression in lung cancer: Jianpi Chutan Jiedu formula reshapes metabolic-immune crosstalk.

發表日期: 2026-04-01

Phytomedicine : international journal of phytotherapy and phytopharmacology

MediLens 收錄日: 2026-04-02

This study investigates the antitumor efficacy of the Jianpi Chutan Jiedu Formula (JCJ) in lung cancer (LC) and its underlying mechanisms. It identifies high expression of XBP1 in LC and demonstrates that Xbp1 overexpression leads to lipid accumulation and immunosuppression in the tumor microenvi...

在PubMed上閱讀
影響力 3

Pediatric Invasive Group A Streptococcus Infections with Central Nervous System Involvement: A Single Institution Case Series in Southern New England.

發表日期: 2026-04-01

Rhode Island medical journal (2013)

MediLens 收錄日: 2026-04-02

This case series highlights three rare pediatric cases of invasive Group A Streptococcus (iGAS) infections with central nervous system involvement, all occurring within a two-month period in Massachusetts. The patients presented with severe conditions, including meningitis and subdural collection...

在PubMed上閱讀

內分泌科5

影響力 3

Development and Validation of Prognostic Models in Patients With Stage IV Thyroid Cancer Undergoing Surgical Treatment.

發表日期: 2026-04-01

The American surgeon

MediLens 收錄日: 2026-04-02

This study addresses the low survival rates in advanced thyroid cancer by developing a prognostic prediction model based on a cohort of 670 patients from the SEER database. Using univariate and multivariate Cox regression analyses, significant independent risk factors were identified, including g...

在PubMed上閱讀
影響力 3

Clinical stage IIA/B embryonal carcinoma predominant nonseminomatous germ cell tumor: Minimizing treatment burden.

發表日期: 2026-04-01

Urologic oncology

MediLens 收錄日: 2026-04-02

This study investigates the treatment burden of primary retroperitoneal lymph node dissection (RPLND) versus chemotherapy in patients with embryonal carcinoma predominance in nonseminomatous germ cell tumors. Among 126 patients, primary RPLND achieved a 3-year recurrence-free survival of 85.1%, w...

在PubMed上閱讀
影響力 3

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

發表日期: 2026-04-01

Archives of endocrinology and metabolism

MediLens 收錄日: 2026-04-02

This case report discusses a 71-year-old woman with poorly differentiated thyroid carcinoma (PDTC) who was ineligible for standard treatments. Molecular profiling indicated a high tumor mutational burden (TMB) and specific somatic mutations. The patient was treated with pembrolizumab, resulting i...

在PubMed上閱讀
影響力 3

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas.

發表日期: 2026-04-01

Journal of cellular and molecular medicine

MediLens 收錄日: 2026-04-02

This study investigates the role of NR3C1 in the invasiveness of nonfunctioning invasive pituitary adenomas (NIPAs). Using RNA-seq and mass spectrometry, the researchers identified NR3C1 as significantly upregulated in NIPAs, with strong discriminatory power in ROC analysis. Functional experiment...

在PubMed上閱讀
影響力 3

USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake.

發表日期: 2026-04-01

Cancer letters

MediLens 收錄日: 2026-04-02

This study identifies a novel mechanism regulating glucose transporter 1 (GLUT1) in pancreatic ductal adenocarcinoma (PDAC) cells through RAB8A-dependent vesicular trafficking. RAB8A enhances GLUT1 localization to the membrane, increasing glucose uptake, while ubiquitin-specific peptidase 20 (USP...

在PubMed上閱讀

腎臟內科5

影響力 3

Elevated triglyceride-glucose index is associated with increased risk of chronic kidney disease and end-stage renal disease in type 1 diabetes: Nationwide cohort study.

發表日期: 2026-04-01

Diabetes, obesity & metabolism

MediLens 收錄日: 2026-04-02

This study investigates the association between the triglyceride-glucose (TyG) index and long-term renal outcomes in a nationwide cohort of 14,782 adults with type 1 diabetes. The findings reveal a significant dose-response relationship, with individuals in the highest quartile of the TyG index h...

在PubMed上閱讀
影響力 3

Ceftriaxone administration reduces vascular calcification associated with experimental models of chronic kidney disease.

發表日期: 2026-04-01

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

MediLens 收錄日: 2026-04-02

This study investigates the effects of gut microbiota depletion on chronic kidney disease (CKD) and vascular calcification (VC) using Wistar rats. The research demonstrates that antibiotic treatment with ceftriaxone significantly lowers serum phosphate levels, reduces uremic toxins, and decreases...

在PubMed上閱讀
影響力 3

Node Positive Resected Renal Cell Carcinoma Portends a Poor Prognosis: Results From the Canadian Kidney Cancer Collaboration.

發表日期: 2026-04-01

Clinical genitourinary cancer

MediLens 收錄日: 2026-04-02

This study investigates the recurrence and survival patterns in patients with pathologically node-positive, nonmetastatic renal cell carcinoma (RCC). A total of 113 patients were analyzed, revealing a 77% recurrence rate at a median of 4.8 months, primarily with distant metastases. The median can...

在PubMed上閱讀
影響力 2

Quality of Life After Abdominal Wall Reconstruction and the Establishment of a Pathway for Renal Transplant Recipients.

發表日期: 2026-04-01

Transplantation proceedings

MediLens 收錄日: 2026-04-02

This study evaluates the outcomes and quality of life (QoL) impact for renal transplant recipients undergoing abdominal wall reconstruction (AWR) for incisional hernia repair. A total of 34 patients were included, with 26 eligible for the QoL survey, and 17 responses received. Complications occur...

在PubMed上閱讀
影響力 2

Minimizing radiation exposure in pediatric nephrolithiasis: The effectiveness of a low-dose computed tomography protocol.

發表日期: 2026-04-01

Journal of pediatric urology

MediLens 收錄日: 2026-04-02

This study reports the development and implementation of a low-dose computed tomography protocol for pediatric nephrolithiasis, aiming to reduce radiation exposure. The protocol demonstrated a significant reduction in radiation dose compared to standard protocols while maintaining diagnostic accu...

在PubMed上閱讀

風濕免疫科3

影響力 2

Incidence of Surgery for Pediatric Wrist Ganglion Cysts.

發表日期: 2026-04-01

Hand (New York, N.Y.)

MediLens 收錄日: 2026-04-02

This study provides a nationwide analysis of pediatric ganglion cysts, highlighting the increasing incidence and surgical management trends with age. A total of 33,884 patients were identified, showing that older patients and females were more likely to undergo surgery. The study emphasizes the i...

在PubMed上閱讀
影響力 1

Certolizumab pegol, abatacept, tocilizumab or active conventional therapy in early rheumatoid arthritis: 48-week patient-reported outcomes from the NORD-STAR trial.

發表日期: 2026-04-01

The Lancet. Rheumatology

MediLens 收錄日: 2026-04-02

(Summary generation failed. Please refer to the original article.)

在PubMed上閱讀
影響力 1

Outcomes and Complications of Suture-Button versus All-Suture Suspensionplasty in Thumb Carpometacarpal Arthritis: A Retrospective Comparative Study.

發表日期: 2026-04-01

The journal of hand surgery Asian-Pacific volume

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

感染科1

影響力 1

An Unusual Cause of Massive Gastrointestinal Bleed in a Girl with Abdominal Tuberculosis.

發表日期: 2026-03-31

Indian pediatrics

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

血液科5

影響力 1

Bronchiolitis Obliterans or Busulfan-Induced Lung Injury? A Pediatric Case of Hematopoietic Stem Cell Transplantation.

發表日期: 2026-04-01

Pediatric pulmonology

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Eosinophilic, polymorphic, and pruritic eruption associated with radiation treated with dupilumab in a patient with Hodgkin lymphoma.

發表日期: 2026-04-01

JAAD case reports

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Bridging therapy before CAR-T for multiple myeloma: a survey from the CMWP and CTIWP of the EBMT.

發表日期: 2026-03-31

Bone marrow transplantation

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Successful Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in X-Linked Sideroblastic Anemia.

發表日期: 2026-03-31

Pediatric blood & cancer

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

HSR26-237: Meta-Analysis Confirms Venetoclax Plus Decitabine as a Frontline Game-Changer in Elderly AML (Acute Myeloid Leukemia).

發表日期: 2026-03-31

Journal of the National Comprehensive Cancer Network : JNCCN

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

精神科1

影響力 1

Correction to "Clinical and Societal Burden of Incident Major Depressive Disorder: A Population-Wide Cohort Study in Stockholm".

發表日期: 2026-04-01

Acta psychiatrica Scandinavica

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

皮膚科5

影響力 1

On the role of cholesterol, vitamin D, lumisterol, and tachysterol signaling in psoriasis.

發表日期: 2026-04-01

The Journal of investigative dermatology

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Successful use of spesolimab in refractory pyoderma gangrenosum.

發表日期: 2026-04-01

JAAD case reports

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Response to Brenaut et al., "Response to Pham et al's 'Sensory symptoms of scalp psoriasis are not sensitive scalp syndrome'".

發表日期: 2026-04-01

JAAD international

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Adults with a history of melanoma have higher odds of laryngeal cancer in the United States.

發表日期: 2026-04-01

JAAD international

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Folate-functionalized core-shell nanocarrier System for sustained and targeted delivery of

發表日期: 2026-04-01

Drug development and industrial pharmacy

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

眼科3

影響力 1

Association between PCSK9 inhibitor use and risk of age-related macular degeneration.

發表日期: 2026-04-01

Eye (London, England)

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Comment on: CATALYZE: a deep learning approach for cataract assessment and grading on SS-OCT images.

發表日期: 2026-04-01

Journal of cataract and refractive surgery

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Comment on: ``Development and Evaluation of an Artificial Intelligence Model to Set Target IOP for Glaucoma''.

發表日期: 2026-04-01

American journal of ophthalmology

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

兒科2

影響力 1

Evaluation of PCORnet as an Approach to Accessing Electronic Health Record (EHR) Data for Cleft Outcomes Research: Advantages and Limitations.

發表日期: 2026-04-01

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Toxic epidermal necrolysis in a preschooler associated with adenovirus respiratory infection: A case report.

發表日期: 2026-04-01

JAAD case reports

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

急診醫學3

影響力 1

Intravenous Access Should Be Prioritized Over Intraosseous Access in Cardiac Arrest.

發表日期: 2026-04-01

Annals of emergency medicine

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

"Perioperative use of factor concentrates and blood products: a survey of clinical practices in the United States: communication from the ISTH Subcommittee on Perioperative and Critical Care": comment from Erdoes et al.

發表日期: 2026-04-01

Journal of thrombosis and haemostasis : JTH

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Ketamine Versus Etomidate in Rapid Sequence Intubation: What Difference Would Convince You?: April 2026 Annals of Emergency Medicine Journal Club.

發表日期: 2026-04-01

Annals of emergency medicine

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

外科5

影響力 1

Intrapericardial congenital diaphragmatic hernia: three-dimensional reconstruction.

發表日期: 2026-04-01

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Displaced kidneys in a giant inguinoscrotal hernia: an unusual cause of hydronephrosis.

發表日期: 2026-04-01

Kidney international

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Local infiltration of liposomal bupivacaine is associated with reduced postoperative admission in anterior abdominal hernia repair.

發表日期: 2026-04-01

Surgery

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Incisional hernia repair using component separation with perforator preservation and onlay mesh: A pilot study.

發表日期: 2026-03-31

Hernia : the journal of hernias and abdominal wall surgery

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Effect of mesh plane on short-term surgical and functional outcomes in ventral hernia repair with associated rectus diastasis.

發表日期: 2026-03-31

Hernia : the journal of hernias and abdominal wall surgery

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

婦產科5

影響力 1

How She Was Born.

發表日期: 2026-04-01

Annals of surgery

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Enhancing diversity in endometriosis clinical trials: Application of the clinical diversity scoring framework.

發表日期: 2026-04-01

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Robotic-assisted transumbilical single-site and transvaginal NOTES resection of abdominal wall cesarean scar endometriosis: Two case reports.

發表日期: 2026-04-01

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Prenatal Diagnosis of Spinal Muscular Atrophy Facilitates Ultrarapid Treatment After Birth.

發表日期: 2026-04-01

Pediatric neurology

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀
影響力 1

Polypoid Endometriosis Mimicking Peritoneal Carcinomatosis.

發表日期: 2026-04-01

Journal of minimally invasive gynecology

MediLens 收錄日: 2026-04-02

(No abstract provided)

在PubMed上閱讀

獲取個人化每日摘要

全球醫生每天早上以AI文獻綜述開始新的一天。每早七點透過郵件發送。

開始7天免費試用