内分泌科5 篇

影响力 3

Development and Validation of Prognostic Models in Patients With Stage IV Thyroid Cancer Undergoing Surgical Treatment.

发表日期: 2026-04-01

The American surgeon

MediLens 收录日: 2026-04-02

This study addresses the low survival rates in advanced thyroid cancer by developing a prognostic prediction model based on a cohort of 670 patients from the SEER database. Using univariate and multivariate Cox regression analyses, significant independent risk factors were identified, including g...

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影响力 3

Clinical stage IIA/B embryonal carcinoma predominant nonseminomatous germ cell tumor: Minimizing treatment burden.

发表日期: 2026-04-01

Urologic oncology

MediLens 收录日: 2026-04-02

This study investigates the treatment burden of primary retroperitoneal lymph node dissection (RPLND) versus chemotherapy in patients with embryonal carcinoma predominance in nonseminomatous germ cell tumors. Among 126 patients, primary RPLND achieved a 3-year recurrence-free survival of 85.1%, w...

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影响力 3

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

发表日期: 2026-04-01

Archives of endocrinology and metabolism

MediLens 收录日: 2026-04-02

This case report discusses a 71-year-old woman with poorly differentiated thyroid carcinoma (PDTC) who was ineligible for standard treatments. Molecular profiling indicated a high tumor mutational burden (TMB) and specific somatic mutations. The patient was treated with pembrolizumab, resulting i...

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影响力 3

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas.

发表日期: 2026-04-01

Journal of cellular and molecular medicine

MediLens 收录日: 2026-04-02

This study investigates the role of NR3C1 in the invasiveness of nonfunctioning invasive pituitary adenomas (NIPAs). Using RNA-seq and mass spectrometry, the researchers identified NR3C1 as significantly upregulated in NIPAs, with strong discriminatory power in ROC analysis. Functional experiment...

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影响力 3

USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake.

发表日期: 2026-04-01

Cancer letters

MediLens 收录日: 2026-04-02

This study identifies a novel mechanism regulating glucose transporter 1 (GLUT1) in pancreatic ductal adenocarcinoma (PDAC) cells through RAB8A-dependent vesicular trafficking. RAB8A enhances GLUT1 localization to the membrane, increasing glucose uptake, while ubiquitin-specific peptidase 20 (USP...

在PubMed上阅读

医学研究趋势

内分泌科5 篇

Development and Validation of Prognostic Models in Patients With Stage IV Thyroid Cancer Undergoing Surgical Treatment.

Clinical stage IIA/B embryonal carcinoma predominant nonseminomatous germ cell tumor: Minimizing treatment burden.

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas.

USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake.

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