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医学研究趋势

AI精选本周最具影响力的29个专科论文

最后更新: 2026年4月1日

心脏病学5

影响力 3

Evolving Strategies in Cardiac Amyloidosis: From Mechanistic Discoveries to Diagnostic and Therapeutic Advances.

发表日期: 2026-04-01

Heart failure clinics

MediLens 收录日: 2026-04-02

The diagnosis and treatment of cardiac amyloidosis have significantly progressed over the last decade, focusing on the pathogenesis of the disease. Noninvasive imaging has enhanced the diagnosis of ATTR cardiomyopathy, while novel treatments, including protein stabilizers and gene editing, have e...

在PubMed上阅读
影响力 3

Surgical Site Infection in Coronary Artery Bypass: Observational Study.

发表日期: 2026-04-01

International journal of nursing practice

MediLens 收录日: 2026-04-02

This observational study assessed adherence to surgical site infection prevention measures in patients undergoing coronary artery bypass grafting at a university hospital. The mean adherence score was 71.18%, but the infection rate was notably high at 55.8%, with some infections leading to hospit...

在PubMed上阅读
影响力 3

Bundled Care Interventions for the Management of Intracerebral Hemorrhage: A Review.

发表日期: 2026-04-01

Critical care nurse

MediLens 收录日: 2026-04-02

The management of spontaneous intracerebral hemorrhage is critical due to its significant impact on disability and mortality. The 2024 American Heart Association/American Stroke Association guidelines recommend bundled care interventions, including blood pressure control and anticoagulation rever...

在PubMed上阅读
影响力 3

Association of insomnia and its proteomic signatures with incident heart failure: A European population-based study.

发表日期: 2026-04-01

Sleep health

MediLens 收录日: 2026-04-02

This study investigates the association between insomnia and heart failure using data from 52,273 participants in the UK Biobank. It finds that insomnia is independently linked to an increased risk of heart failure (HR: 1.39; 95% CI: 1.17-1.65) and identifies 118 proteins related to insomnia that...

在PubMed上阅读
影响力 2

Decreased AMP-kinase function in pulmonary artery smooth muscle cells contributes to pulmonary artery remodeling in persistent pulmonary hypertension of the newborn.

发表日期: 2026-04-01

American journal of physiology. Lung cellular and molecular physiology

MediLens 收录日: 2026-04-02

This study investigates the role of decreased AMPK function in pulmonary artery smooth muscle cells (PASMCs) in the context of persistent pulmonary hypertension of the newborn (PPHN). Using fetal lambs, the research reveals that PPHN is associated with decreased levels of phosphorylated AMPK, PGC...

在PubMed上阅读

肿瘤科1

影响力 1

Bridging mechanism and clinic: unlocking the full potential of oncolytic virus-based immunotherapy.

发表日期: 2026-03-31

Molecular cancer

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

神经内科1

影响力 1

Retraction Note: An intelligent learning system based on electronic health records for unbiased stroke prediction.

发表日期: 2026-03-31

Scientific reports

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

消化内科5

影响力 3

Bifunctional nanoparticles based on esterified hydroxypropyl β-cyclodextrin/quaternary ammonium chitosan for ulcerative colitis intervention.

发表日期: 2026-04-01

Food research international (Ottawa, Ont.)

MediLens 收录日: 2026-04-02

This study presents a novel approach to ulcerative colitis therapy using oral nanoparticles that combine anti-inflammatory effects with gut microbiome modulation. The nanoparticles, developed through self-assembly, utilize curcumin for its anti-inflammatory properties and anthocyanin for microbio...

在PubMed上阅读
影响力 3

Exploration of a Model for Elimination of Hepatitis C in Women of Childbearing Age in Primary Hospitals in Southern China.

发表日期: 2026-04-01

Journal of viral hepatitis

MediLens 收录日: 2026-04-02

This study evaluated an intervention model for Hepatitis C virus (HCV) elimination in women of childbearing age, focusing on 'treatment as prevention'. Launched in October 2022, the project enhanced HCV-Ab screening, RNA testing, and treatment referrals through multidisciplinary collaborations. K...

在PubMed上阅读
影响力 3

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study.

发表日期: 2026-04-01

Liver international : official journal of the International Association for the Study of the Liver

MediLens 收录日: 2026-04-02

This study analyzed outcomes in 571 patients who underwent liver transplantation for primary sclerosing cholangitis (PSC) in France from 1985 to 2019. The median follow-up was 89 months, with patient survival rates at 5, 10, and 20 years being 88.2%, 81.2%, and 62.6%, respectively. Graft survival...

在PubMed上阅读
影响力 3

Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2.

发表日期: 2026-04-01

Chemical biology & drug design

MediLens 收录日: 2026-04-02

This study investigates the cytotoxic effects of sulfonated silver(I) and gold(I) N-heterocyclic carbene complexes on human liver cancer cells. The results indicate that these complexes induce autophagic cell death rather than apoptosis, characterized by increased expression of autophagy markers ...

在PubMed上阅读
影响力 3

Phytogalactolipids triggered oxidative stress to inhibit drug-resistant colorectal cancer by suppressing interferon-α-induced protein 6.

发表日期: 2026-04-01

Phytomedicine : international journal of phytotherapy and phytopharmacology

MediLens 收录日: 2026-04-02

This study investigates the pharmacological mechanism and therapeutic efficacy of galactolipids from Crassocephalum rabens (CRA) for treating drug-resistant colorectal cancer (CRC). CRA demonstrated antitumor activity by inducing ROS-mediated cytotoxicity through the inhibition of IFI6 expression...

在PubMed上阅读

呼吸内科5

影响力 3

Upfront treatment with osimertinib in lung cancer patients with and without active brain metastases, and the role of ctDNA as a biomarker; a phase II clinical trial (the FIOL study).

发表日期: 2026-04-01

Lung cancer (Amsterdam, Netherlands)

MediLens 收录日: 2026-04-02

This phase II trial evaluated the efficacy of osimertinib in patients with EGFR-mutated non-small cell lung cancer, focusing on those with untreated brain metastases. The study included 100 patients, showing an overall objective response rate of 72.0%, with 81.8% in those with measurable brain me...

在PubMed上阅读
影响力 3

Overall survival for amivantamab plus lazertinib versus osimertinib as first-line treatment in Asian participants with EGFR-mutant advanced NSCLC: A MARIPOSA subset analysis.

发表日期: 2026-04-01

Lung cancer (Amsterdam, Netherlands)

MediLens 收录日: 2026-04-02

The study evaluated the overall survival (OS) of amivantamab-lazertinib compared to osimertinib in Asian patients with untreated EGFR-mutated advanced non-small cell lung cancer (NSCLC). Results showed a significant improvement in OS for amivantamab-lazertinib, with a hazard ratio of 0.74 at a me...

在PubMed上阅读
影响力 3

Defining response-adapted surgery after neoadjuvant systemic therapy in sinonasal squamous cell carcinoma.

发表日期: 2026-04-01

Oral oncology

MediLens 收录日: 2026-04-02

This study presents a novel classification system for documenting surgical outcomes in patients with sinonasal squamous cell carcinoma (SCC) undergoing neoadjuvant therapy. The framework addresses the complexities of sinonasal anatomy and aims to standardize the evaluation of surgical morbidity a...

在PubMed上阅读
影响力 3

Xbp1-driven lipid metabolism promotes immunosuppression in lung cancer: Jianpi Chutan Jiedu formula reshapes metabolic-immune crosstalk.

发表日期: 2026-04-01

Phytomedicine : international journal of phytotherapy and phytopharmacology

MediLens 收录日: 2026-04-02

This study investigates the antitumor efficacy of the Jianpi Chutan Jiedu Formula (JCJ) in lung cancer (LC) and its underlying mechanisms. It identifies high expression of XBP1 in LC and demonstrates that Xbp1 overexpression leads to lipid accumulation and immunosuppression in the tumor microenvi...

在PubMed上阅读
影响力 3

Pediatric Invasive Group A Streptococcus Infections with Central Nervous System Involvement: A Single Institution Case Series in Southern New England.

发表日期: 2026-04-01

Rhode Island medical journal (2013)

MediLens 收录日: 2026-04-02

This case series highlights three rare pediatric cases of invasive Group A Streptococcus (iGAS) infections with central nervous system involvement, all occurring within a two-month period in Massachusetts. The patients presented with severe conditions, including meningitis and subdural collection...

在PubMed上阅读

内分泌科5

影响力 3

Development and Validation of Prognostic Models in Patients With Stage IV Thyroid Cancer Undergoing Surgical Treatment.

发表日期: 2026-04-01

The American surgeon

MediLens 收录日: 2026-04-02

This study addresses the low survival rates in advanced thyroid cancer by developing a prognostic prediction model based on a cohort of 670 patients from the SEER database. Using univariate and multivariate Cox regression analyses, significant independent risk factors were identified, including g...

在PubMed上阅读
影响力 3

Clinical stage IIA/B embryonal carcinoma predominant nonseminomatous germ cell tumor: Minimizing treatment burden.

发表日期: 2026-04-01

Urologic oncology

MediLens 收录日: 2026-04-02

This study investigates the treatment burden of primary retroperitoneal lymph node dissection (RPLND) versus chemotherapy in patients with embryonal carcinoma predominance in nonseminomatous germ cell tumors. Among 126 patients, primary RPLND achieved a 3-year recurrence-free survival of 85.1%, w...

在PubMed上阅读
影响力 3

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

发表日期: 2026-04-01

Archives of endocrinology and metabolism

MediLens 收录日: 2026-04-02

This case report discusses a 71-year-old woman with poorly differentiated thyroid carcinoma (PDTC) who was ineligible for standard treatments. Molecular profiling indicated a high tumor mutational burden (TMB) and specific somatic mutations. The patient was treated with pembrolizumab, resulting i...

在PubMed上阅读
影响力 3

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas.

发表日期: 2026-04-01

Journal of cellular and molecular medicine

MediLens 收录日: 2026-04-02

This study investigates the role of NR3C1 in the invasiveness of nonfunctioning invasive pituitary adenomas (NIPAs). Using RNA-seq and mass spectrometry, the researchers identified NR3C1 as significantly upregulated in NIPAs, with strong discriminatory power in ROC analysis. Functional experiment...

在PubMed上阅读
影响力 3

USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake.

发表日期: 2026-04-01

Cancer letters

MediLens 收录日: 2026-04-02

This study identifies a novel mechanism regulating glucose transporter 1 (GLUT1) in pancreatic ductal adenocarcinoma (PDAC) cells through RAB8A-dependent vesicular trafficking. RAB8A enhances GLUT1 localization to the membrane, increasing glucose uptake, while ubiquitin-specific peptidase 20 (USP...

在PubMed上阅读

肾脏内科5

影响力 3

Elevated triglyceride-glucose index is associated with increased risk of chronic kidney disease and end-stage renal disease in type 1 diabetes: Nationwide cohort study.

发表日期: 2026-04-01

Diabetes, obesity & metabolism

MediLens 收录日: 2026-04-02

This study investigates the association between the triglyceride-glucose (TyG) index and long-term renal outcomes in a nationwide cohort of 14,782 adults with type 1 diabetes. The findings reveal a significant dose-response relationship, with individuals in the highest quartile of the TyG index h...

在PubMed上阅读
影响力 3

Ceftriaxone administration reduces vascular calcification associated with experimental models of chronic kidney disease.

发表日期: 2026-04-01

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

MediLens 收录日: 2026-04-02

This study investigates the effects of gut microbiota depletion on chronic kidney disease (CKD) and vascular calcification (VC) using Wistar rats. The research demonstrates that antibiotic treatment with ceftriaxone significantly lowers serum phosphate levels, reduces uremic toxins, and decreases...

在PubMed上阅读
影响力 3

Node Positive Resected Renal Cell Carcinoma Portends a Poor Prognosis: Results From the Canadian Kidney Cancer Collaboration.

发表日期: 2026-04-01

Clinical genitourinary cancer

MediLens 收录日: 2026-04-02

This study investigates the recurrence and survival patterns in patients with pathologically node-positive, nonmetastatic renal cell carcinoma (RCC). A total of 113 patients were analyzed, revealing a 77% recurrence rate at a median of 4.8 months, primarily with distant metastases. The median can...

在PubMed上阅读
影响力 2

Quality of Life After Abdominal Wall Reconstruction and the Establishment of a Pathway for Renal Transplant Recipients.

发表日期: 2026-04-01

Transplantation proceedings

MediLens 收录日: 2026-04-02

This study evaluates the outcomes and quality of life (QoL) impact for renal transplant recipients undergoing abdominal wall reconstruction (AWR) for incisional hernia repair. A total of 34 patients were included, with 26 eligible for the QoL survey, and 17 responses received. Complications occur...

在PubMed上阅读
影响力 2

Minimizing radiation exposure in pediatric nephrolithiasis: The effectiveness of a low-dose computed tomography protocol.

发表日期: 2026-04-01

Journal of pediatric urology

MediLens 收录日: 2026-04-02

This study reports the development and implementation of a low-dose computed tomography protocol for pediatric nephrolithiasis, aiming to reduce radiation exposure. The protocol demonstrated a significant reduction in radiation dose compared to standard protocols while maintaining diagnostic accu...

在PubMed上阅读

风湿免疫科3

影响力 2

Incidence of Surgery for Pediatric Wrist Ganglion Cysts.

发表日期: 2026-04-01

Hand (New York, N.Y.)

MediLens 收录日: 2026-04-02

This study provides a nationwide analysis of pediatric ganglion cysts, highlighting the increasing incidence and surgical management trends with age. A total of 33,884 patients were identified, showing that older patients and females were more likely to undergo surgery. The study emphasizes the i...

在PubMed上阅读
影响力 1

Certolizumab pegol, abatacept, tocilizumab or active conventional therapy in early rheumatoid arthritis: 48-week patient-reported outcomes from the NORD-STAR trial.

发表日期: 2026-04-01

The Lancet. Rheumatology

MediLens 收录日: 2026-04-02

(Summary generation failed. Please refer to the original article.)

在PubMed上阅读
影响力 1

Outcomes and Complications of Suture-Button versus All-Suture Suspensionplasty in Thumb Carpometacarpal Arthritis: A Retrospective Comparative Study.

发表日期: 2026-04-01

The journal of hand surgery Asian-Pacific volume

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

感染科1

影响力 1

An Unusual Cause of Massive Gastrointestinal Bleed in a Girl with Abdominal Tuberculosis.

发表日期: 2026-03-31

Indian pediatrics

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

血液科5

影响力 1

Bronchiolitis Obliterans or Busulfan-Induced Lung Injury? A Pediatric Case of Hematopoietic Stem Cell Transplantation.

发表日期: 2026-04-01

Pediatric pulmonology

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Eosinophilic, polymorphic, and pruritic eruption associated with radiation treated with dupilumab in a patient with Hodgkin lymphoma.

发表日期: 2026-04-01

JAAD case reports

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Bridging therapy before CAR-T for multiple myeloma: a survey from the CMWP and CTIWP of the EBMT.

发表日期: 2026-03-31

Bone marrow transplantation

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Successful Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in X-Linked Sideroblastic Anemia.

发表日期: 2026-03-31

Pediatric blood & cancer

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

HSR26-237: Meta-Analysis Confirms Venetoclax Plus Decitabine as a Frontline Game-Changer in Elderly AML (Acute Myeloid Leukemia).

发表日期: 2026-03-31

Journal of the National Comprehensive Cancer Network : JNCCN

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

精神科1

影响力 1

Correction to "Clinical and Societal Burden of Incident Major Depressive Disorder: A Population-Wide Cohort Study in Stockholm".

发表日期: 2026-04-01

Acta psychiatrica Scandinavica

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

皮肤科5

影响力 1

On the role of cholesterol, vitamin D, lumisterol, and tachysterol signaling in psoriasis.

发表日期: 2026-04-01

The Journal of investigative dermatology

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Successful use of spesolimab in refractory pyoderma gangrenosum.

发表日期: 2026-04-01

JAAD case reports

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Response to Brenaut et al., "Response to Pham et al's 'Sensory symptoms of scalp psoriasis are not sensitive scalp syndrome'".

发表日期: 2026-04-01

JAAD international

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Adults with a history of melanoma have higher odds of laryngeal cancer in the United States.

发表日期: 2026-04-01

JAAD international

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Folate-functionalized core-shell nanocarrier System for sustained and targeted delivery of

发表日期: 2026-04-01

Drug development and industrial pharmacy

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

眼科3

影响力 1

Association between PCSK9 inhibitor use and risk of age-related macular degeneration.

发表日期: 2026-04-01

Eye (London, England)

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Comment on: CATALYZE: a deep learning approach for cataract assessment and grading on SS-OCT images.

发表日期: 2026-04-01

Journal of cataract and refractive surgery

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Comment on: ``Development and Evaluation of an Artificial Intelligence Model to Set Target IOP for Glaucoma''.

发表日期: 2026-04-01

American journal of ophthalmology

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

儿科2

影响力 1

Evaluation of PCORnet as an Approach to Accessing Electronic Health Record (EHR) Data for Cleft Outcomes Research: Advantages and Limitations.

发表日期: 2026-04-01

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Toxic epidermal necrolysis in a preschooler associated with adenovirus respiratory infection: A case report.

发表日期: 2026-04-01

JAAD case reports

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

急诊医学3

影响力 1

Intravenous Access Should Be Prioritized Over Intraosseous Access in Cardiac Arrest.

发表日期: 2026-04-01

Annals of emergency medicine

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

"Perioperative use of factor concentrates and blood products: a survey of clinical practices in the United States: communication from the ISTH Subcommittee on Perioperative and Critical Care": comment from Erdoes et al.

发表日期: 2026-04-01

Journal of thrombosis and haemostasis : JTH

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Ketamine Versus Etomidate in Rapid Sequence Intubation: What Difference Would Convince You?: April 2026 Annals of Emergency Medicine Journal Club.

发表日期: 2026-04-01

Annals of emergency medicine

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

外科5

影响力 1

Intrapericardial congenital diaphragmatic hernia: three-dimensional reconstruction.

发表日期: 2026-04-01

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Displaced kidneys in a giant inguinoscrotal hernia: an unusual cause of hydronephrosis.

发表日期: 2026-04-01

Kidney international

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Local infiltration of liposomal bupivacaine is associated with reduced postoperative admission in anterior abdominal hernia repair.

发表日期: 2026-04-01

Surgery

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Incisional hernia repair using component separation with perforator preservation and onlay mesh: A pilot study.

发表日期: 2026-03-31

Hernia : the journal of hernias and abdominal wall surgery

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Effect of mesh plane on short-term surgical and functional outcomes in ventral hernia repair with associated rectus diastasis.

发表日期: 2026-03-31

Hernia : the journal of hernias and abdominal wall surgery

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

妇产科5

影响力 1

How She Was Born.

发表日期: 2026-04-01

Annals of surgery

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Enhancing diversity in endometriosis clinical trials: Application of the clinical diversity scoring framework.

发表日期: 2026-04-01

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Robotic-assisted transumbilical single-site and transvaginal NOTES resection of abdominal wall cesarean scar endometriosis: Two case reports.

发表日期: 2026-04-01

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Prenatal Diagnosis of Spinal Muscular Atrophy Facilitates Ultrarapid Treatment After Birth.

发表日期: 2026-04-01

Pediatric neurology

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读
影响力 1

Polypoid Endometriosis Mimicking Peritoneal Carcinomatosis.

发表日期: 2026-04-01

Journal of minimally invasive gynecology

MediLens 收录日: 2026-04-02

(No abstract provided)

在PubMed上阅读

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