Medical Research Trends

This week's highest-impact publications across 29 specialties, curated by AI

Last updated: 1 de abr. de 2026

Cardiology5 articles

Impact 3

Evolving Strategies in Cardiac Amyloidosis: From Mechanistic Discoveries to Diagnostic and Therapeutic Advances.

Published: 2026-04-01

Heart failure clinics

MediLens Indexed: 2026-04-02

The diagnosis and treatment of cardiac amyloidosis have significantly progressed over the last decade, focusing on the pathogenesis of the disease. Noninvasive imaging has enhanced the diagnosis of ATTR cardiomyopathy, while novel treatments, including protein stabilizers and gene editing, have e...

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Impact 3

Surgical Site Infection in Coronary Artery Bypass: Observational Study.

Published: 2026-04-01

International journal of nursing practice

MediLens Indexed: 2026-04-02

This observational study assessed adherence to surgical site infection prevention measures in patients undergoing coronary artery bypass grafting at a university hospital. The mean adherence score was 71.18%, but the infection rate was notably high at 55.8%, with some infections leading to hospit...

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Impact 3

Bundled Care Interventions for the Management of Intracerebral Hemorrhage: A Review.

Published: 2026-04-01

Critical care nurse

MediLens Indexed: 2026-04-02

The management of spontaneous intracerebral hemorrhage is critical due to its significant impact on disability and mortality. The 2024 American Heart Association/American Stroke Association guidelines recommend bundled care interventions, including blood pressure control and anticoagulation rever...

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Impact 3

Association of insomnia and its proteomic signatures with incident heart failure: A European population-based study.

Published: 2026-04-01

Sleep health

MediLens Indexed: 2026-04-02

This study investigates the association between insomnia and heart failure using data from 52,273 participants in the UK Biobank. It finds that insomnia is independently linked to an increased risk of heart failure (HR: 1.39; 95% CI: 1.17-1.65) and identifies 118 proteins related to insomnia that...

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Impact 2

Decreased AMP-kinase function in pulmonary artery smooth muscle cells contributes to pulmonary artery remodeling in persistent pulmonary hypertension of the newborn.

Published: 2026-04-01

American journal of physiology. Lung cellular and molecular physiology

MediLens Indexed: 2026-04-02

This study investigates the role of decreased AMPK function in pulmonary artery smooth muscle cells (PASMCs) in the context of persistent pulmonary hypertension of the newborn (PPHN). Using fetal lambs, the research reveals that PPHN is associated with decreased levels of phosphorylated AMPK, PGC...

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Oncology1 articles

Impact 1

Bridging mechanism and clinic: unlocking the full potential of oncolytic virus-based immunotherapy.

Published: 2026-03-31

Molecular cancer

MediLens Indexed: 2026-04-02

(No abstract provided)

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Neurology1 articles

Impact 1

Retraction Note: An intelligent learning system based on electronic health records for unbiased stroke prediction.

Published: 2026-03-31

Scientific reports

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Gastroenterology5 articles

Impact 3

Bifunctional nanoparticles based on esterified hydroxypropyl β-cyclodextrin/quaternary ammonium chitosan for ulcerative colitis intervention.

Published: 2026-04-01

Food research international (Ottawa, Ont.)

MediLens Indexed: 2026-04-02

This study presents a novel approach to ulcerative colitis therapy using oral nanoparticles that combine anti-inflammatory effects with gut microbiome modulation. The nanoparticles, developed through self-assembly, utilize curcumin for its anti-inflammatory properties and anthocyanin for microbio...

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Impact 3

Exploration of a Model for Elimination of Hepatitis C in Women of Childbearing Age in Primary Hospitals in Southern China.

Published: 2026-04-01

Journal of viral hepatitis

MediLens Indexed: 2026-04-02

This study evaluated an intervention model for Hepatitis C virus (HCV) elimination in women of childbearing age, focusing on 'treatment as prevention'. Launched in October 2022, the project enhanced HCV-Ab screening, RNA testing, and treatment referrals through multidisciplinary collaborations. K...

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Impact 3

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study.

Published: 2026-04-01

Liver international : official journal of the International Association for the Study of the Liver

MediLens Indexed: 2026-04-02

This study analyzed outcomes in 571 patients who underwent liver transplantation for primary sclerosing cholangitis (PSC) in France from 1985 to 2019. The median follow-up was 89 months, with patient survival rates at 5, 10, and 20 years being 88.2%, 81.2%, and 62.6%, respectively. Graft survival...

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Impact 3

Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2.

Published: 2026-04-01

Chemical biology & drug design

MediLens Indexed: 2026-04-02

This study investigates the cytotoxic effects of sulfonated silver(I) and gold(I) N-heterocyclic carbene complexes on human liver cancer cells. The results indicate that these complexes induce autophagic cell death rather than apoptosis, characterized by increased expression of autophagy markers ...

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Impact 3

Phytogalactolipids triggered oxidative stress to inhibit drug-resistant colorectal cancer by suppressing interferon-α-induced protein 6.

Published: 2026-04-01

Phytomedicine : international journal of phytotherapy and phytopharmacology

MediLens Indexed: 2026-04-02

This study investigates the pharmacological mechanism and therapeutic efficacy of galactolipids from Crassocephalum rabens (CRA) for treating drug-resistant colorectal cancer (CRC). CRA demonstrated antitumor activity by inducing ROS-mediated cytotoxicity through the inhibition of IFI6 expression...

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Pulmonology5 articles

Impact 3

Upfront treatment with osimertinib in lung cancer patients with and without active brain metastases, and the role of ctDNA as a biomarker; a phase II clinical trial (the FIOL study).

Published: 2026-04-01

Lung cancer (Amsterdam, Netherlands)

MediLens Indexed: 2026-04-02

This phase II trial evaluated the efficacy of osimertinib in patients with EGFR-mutated non-small cell lung cancer, focusing on those with untreated brain metastases. The study included 100 patients, showing an overall objective response rate of 72.0%, with 81.8% in those with measurable brain me...

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Impact 3

Overall survival for amivantamab plus lazertinib versus osimertinib as first-line treatment in Asian participants with EGFR-mutant advanced NSCLC: A MARIPOSA subset analysis.

Published: 2026-04-01

Lung cancer (Amsterdam, Netherlands)

MediLens Indexed: 2026-04-02

The study evaluated the overall survival (OS) of amivantamab-lazertinib compared to osimertinib in Asian patients with untreated EGFR-mutated advanced non-small cell lung cancer (NSCLC). Results showed a significant improvement in OS for amivantamab-lazertinib, with a hazard ratio of 0.74 at a me...

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Impact 3

Defining response-adapted surgery after neoadjuvant systemic therapy in sinonasal squamous cell carcinoma.

Published: 2026-04-01

Oral oncology

MediLens Indexed: 2026-04-02

This study presents a novel classification system for documenting surgical outcomes in patients with sinonasal squamous cell carcinoma (SCC) undergoing neoadjuvant therapy. The framework addresses the complexities of sinonasal anatomy and aims to standardize the evaluation of surgical morbidity a...

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Impact 3

Xbp1-driven lipid metabolism promotes immunosuppression in lung cancer: Jianpi Chutan Jiedu formula reshapes metabolic-immune crosstalk.

Published: 2026-04-01

Phytomedicine : international journal of phytotherapy and phytopharmacology

MediLens Indexed: 2026-04-02

This study investigates the antitumor efficacy of the Jianpi Chutan Jiedu Formula (JCJ) in lung cancer (LC) and its underlying mechanisms. It identifies high expression of XBP1 in LC and demonstrates that Xbp1 overexpression leads to lipid accumulation and immunosuppression in the tumor microenvi...

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Impact 3

Pediatric Invasive Group A Streptococcus Infections with Central Nervous System Involvement: A Single Institution Case Series in Southern New England.

Published: 2026-04-01

Rhode Island medical journal (2013)

MediLens Indexed: 2026-04-02

This case series highlights three rare pediatric cases of invasive Group A Streptococcus (iGAS) infections with central nervous system involvement, all occurring within a two-month period in Massachusetts. The patients presented with severe conditions, including meningitis and subdural collection...

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Endocrinology5 articles

Impact 3

Development and Validation of Prognostic Models in Patients With Stage IV Thyroid Cancer Undergoing Surgical Treatment.

Published: 2026-04-01

The American surgeon

MediLens Indexed: 2026-04-02

This study addresses the low survival rates in advanced thyroid cancer by developing a prognostic prediction model based on a cohort of 670 patients from the SEER database. Using univariate and multivariate Cox regression analyses, significant independent risk factors were identified, including g...

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Impact 3

Clinical stage IIA/B embryonal carcinoma predominant nonseminomatous germ cell tumor: Minimizing treatment burden.

Published: 2026-04-01

Urologic oncology

MediLens Indexed: 2026-04-02

This study investigates the treatment burden of primary retroperitoneal lymph node dissection (RPLND) versus chemotherapy in patients with embryonal carcinoma predominance in nonseminomatous germ cell tumors. Among 126 patients, primary RPLND achieved a 3-year recurrence-free survival of 85.1%, w...

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Impact 3

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

Published: 2026-04-01

Archives of endocrinology and metabolism

MediLens Indexed: 2026-04-02

This case report discusses a 71-year-old woman with poorly differentiated thyroid carcinoma (PDTC) who was ineligible for standard treatments. Molecular profiling indicated a high tumor mutational burden (TMB) and specific somatic mutations. The patient was treated with pembrolizumab, resulting i...

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Impact 3

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas.

Published: 2026-04-01

Journal of cellular and molecular medicine

MediLens Indexed: 2026-04-02

This study investigates the role of NR3C1 in the invasiveness of nonfunctioning invasive pituitary adenomas (NIPAs). Using RNA-seq and mass spectrometry, the researchers identified NR3C1 as significantly upregulated in NIPAs, with strong discriminatory power in ROC analysis. Functional experiment...

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Impact 3

USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake.

Published: 2026-04-01

Cancer letters

MediLens Indexed: 2026-04-02

This study identifies a novel mechanism regulating glucose transporter 1 (GLUT1) in pancreatic ductal adenocarcinoma (PDAC) cells through RAB8A-dependent vesicular trafficking. RAB8A enhances GLUT1 localization to the membrane, increasing glucose uptake, while ubiquitin-specific peptidase 20 (USP...

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Nephrology5 articles

Impact 3

Elevated triglyceride-glucose index is associated with increased risk of chronic kidney disease and end-stage renal disease in type 1 diabetes: Nationwide cohort study.

Published: 2026-04-01

Diabetes, obesity & metabolism

MediLens Indexed: 2026-04-02

This study investigates the association between the triglyceride-glucose (TyG) index and long-term renal outcomes in a nationwide cohort of 14,782 adults with type 1 diabetes. The findings reveal a significant dose-response relationship, with individuals in the highest quartile of the TyG index h...

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Impact 3

Ceftriaxone administration reduces vascular calcification associated with experimental models of chronic kidney disease.

Published: 2026-04-01

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

MediLens Indexed: 2026-04-02

This study investigates the effects of gut microbiota depletion on chronic kidney disease (CKD) and vascular calcification (VC) using Wistar rats. The research demonstrates that antibiotic treatment with ceftriaxone significantly lowers serum phosphate levels, reduces uremic toxins, and decreases...

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Impact 3

Node Positive Resected Renal Cell Carcinoma Portends a Poor Prognosis: Results From the Canadian Kidney Cancer Collaboration.

Published: 2026-04-01

Clinical genitourinary cancer

MediLens Indexed: 2026-04-02

This study investigates the recurrence and survival patterns in patients with pathologically node-positive, nonmetastatic renal cell carcinoma (RCC). A total of 113 patients were analyzed, revealing a 77% recurrence rate at a median of 4.8 months, primarily with distant metastases. The median can...

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Impact 2

Quality of Life After Abdominal Wall Reconstruction and the Establishment of a Pathway for Renal Transplant Recipients.

Published: 2026-04-01

Transplantation proceedings

MediLens Indexed: 2026-04-02

This study evaluates the outcomes and quality of life (QoL) impact for renal transplant recipients undergoing abdominal wall reconstruction (AWR) for incisional hernia repair. A total of 34 patients were included, with 26 eligible for the QoL survey, and 17 responses received. Complications occur...

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Impact 2

Minimizing radiation exposure in pediatric nephrolithiasis: The effectiveness of a low-dose computed tomography protocol.

Published: 2026-04-01

Journal of pediatric urology

MediLens Indexed: 2026-04-02

This study reports the development and implementation of a low-dose computed tomography protocol for pediatric nephrolithiasis, aiming to reduce radiation exposure. The protocol demonstrated a significant reduction in radiation dose compared to standard protocols while maintaining diagnostic accu...

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Rheumatology3 articles

Impact 2

Incidence of Surgery for Pediatric Wrist Ganglion Cysts.

Published: 2026-04-01

Hand (New York, N.Y.)

MediLens Indexed: 2026-04-02

This study provides a nationwide analysis of pediatric ganglion cysts, highlighting the increasing incidence and surgical management trends with age. A total of 33,884 patients were identified, showing that older patients and females were more likely to undergo surgery. The study emphasizes the i...

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Impact 1

Certolizumab pegol, abatacept, tocilizumab or active conventional therapy in early rheumatoid arthritis: 48-week patient-reported outcomes from the NORD-STAR trial.

Published: 2026-04-01

The Lancet. Rheumatology

MediLens Indexed: 2026-04-02

(Summary generation failed. Please refer to the original article.)

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Impact 1

Outcomes and Complications of Suture-Button versus All-Suture Suspensionplasty in Thumb Carpometacarpal Arthritis: A Retrospective Comparative Study.

Published: 2026-04-01

The journal of hand surgery Asian-Pacific volume

MediLens Indexed: 2026-04-02

(No abstract provided)

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Infectious Disease1 articles

Impact 1

An Unusual Cause of Massive Gastrointestinal Bleed in a Girl with Abdominal Tuberculosis.

Published: 2026-03-31

Indian pediatrics

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Hematology5 articles

Impact 1

Bronchiolitis Obliterans or Busulfan-Induced Lung Injury? A Pediatric Case of Hematopoietic Stem Cell Transplantation.

Published: 2026-04-01

Pediatric pulmonology

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Eosinophilic, polymorphic, and pruritic eruption associated with radiation treated with dupilumab in a patient with Hodgkin lymphoma.

Published: 2026-04-01

JAAD case reports

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Bridging therapy before CAR-T for multiple myeloma: a survey from the CMWP and CTIWP of the EBMT.

Published: 2026-03-31

Bone marrow transplantation

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Successful Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in X-Linked Sideroblastic Anemia.

Published: 2026-03-31

Pediatric blood & cancer

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

HSR26-237: Meta-Analysis Confirms Venetoclax Plus Decitabine as a Frontline Game-Changer in Elderly AML (Acute Myeloid Leukemia).

Published: 2026-03-31

Journal of the National Comprehensive Cancer Network : JNCCN

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Psychiatry1 articles

Impact 1

Correction to "Clinical and Societal Burden of Incident Major Depressive Disorder: A Population-Wide Cohort Study in Stockholm".

Published: 2026-04-01

Acta psychiatrica Scandinavica

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Dermatology5 articles

Impact 1

On the role of cholesterol, vitamin D, lumisterol, and tachysterol signaling in psoriasis.

Published: 2026-04-01

The Journal of investigative dermatology

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Successful use of spesolimab in refractory pyoderma gangrenosum.

Published: 2026-04-01

JAAD case reports

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Response to Brenaut et al., "Response to Pham et al's 'Sensory symptoms of scalp psoriasis are not sensitive scalp syndrome'".

Published: 2026-04-01

JAAD international

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Adults with a history of melanoma have higher odds of laryngeal cancer in the United States.

Published: 2026-04-01

JAAD international

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Folate-functionalized core-shell nanocarrier System for sustained and targeted delivery of

Published: 2026-04-01

Drug development and industrial pharmacy

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Ophthalmology3 articles

Impact 1

Association between PCSK9 inhibitor use and risk of age-related macular degeneration.

Published: 2026-04-01

Eye (London, England)

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Comment on: CATALYZE: a deep learning approach for cataract assessment and grading on SS-OCT images.

Published: 2026-04-01

Journal of cataract and refractive surgery

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Comment on: ``Development and Evaluation of an Artificial Intelligence Model to Set Target IOP for Glaucoma''.

Published: 2026-04-01

American journal of ophthalmology

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Pediatrics2 articles

Impact 1

Evaluation of PCORnet as an Approach to Accessing Electronic Health Record (EHR) Data for Cleft Outcomes Research: Advantages and Limitations.

Published: 2026-04-01

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Toxic epidermal necrolysis in a preschooler associated with adenovirus respiratory infection: A case report.

Published: 2026-04-01

JAAD case reports

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Emergency Medicine3 articles

Impact 1

Intravenous Access Should Be Prioritized Over Intraosseous Access in Cardiac Arrest.

Published: 2026-04-01

Annals of emergency medicine

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

"Perioperative use of factor concentrates and blood products: a survey of clinical practices in the United States: communication from the ISTH Subcommittee on Perioperative and Critical Care": comment from Erdoes et al.

Published: 2026-04-01

Journal of thrombosis and haemostasis : JTH

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Ketamine Versus Etomidate in Rapid Sequence Intubation: What Difference Would Convince You?: April 2026 Annals of Emergency Medicine Journal Club.

Published: 2026-04-01

Annals of emergency medicine

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Surgery5 articles

Impact 1

Intrapericardial congenital diaphragmatic hernia: three-dimensional reconstruction.

Published: 2026-04-01

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Displaced kidneys in a giant inguinoscrotal hernia: an unusual cause of hydronephrosis.

Published: 2026-04-01

Kidney international

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Local infiltration of liposomal bupivacaine is associated with reduced postoperative admission in anterior abdominal hernia repair.

Published: 2026-04-01

Surgery

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Incisional hernia repair using component separation with perforator preservation and onlay mesh: A pilot study.

Published: 2026-03-31

Hernia : the journal of hernias and abdominal wall surgery

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Effect of mesh plane on short-term surgical and functional outcomes in ventral hernia repair with associated rectus diastasis.

Published: 2026-03-31

Hernia : the journal of hernias and abdominal wall surgery

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

Obstetrics & Gynecology5 articles

Impact 1

How She Was Born.

Published: 2026-04-01

Annals of surgery

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Enhancing diversity in endometriosis clinical trials: Application of the clinical diversity scoring framework.

Published: 2026-04-01

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Robotic-assisted transumbilical single-site and transvaginal NOTES resection of abdominal wall cesarean scar endometriosis: Two case reports.

Published: 2026-04-01

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Prenatal Diagnosis of Spinal Muscular Atrophy Facilitates Ultrarapid Treatment After Birth.

Published: 2026-04-01

Pediatric neurology

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed
Impact 1

Polypoid Endometriosis Mimicking Peritoneal Carcinomatosis.

Published: 2026-04-01

Journal of minimally invasive gynecology

MediLens Indexed: 2026-04-02

(No abstract provided)

Read on PubMed

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