Medical Research Trends

This week's highest-impact publications across 29 specialties, curated by AI

Last updated: 11 de mai. de 2026

Cardiology5 articles

Impact 2

Day-of-the-week variation in ischemic stroke admissions in patients with atrial fibrillation.

Published: 2026-12-01

Annals of medicine

MediLens Indexed: 2026-05-12

This study investigates the variation in ischemic stroke admissions among patients with atrial fibrillation (AF) based on the day of the week. Analyzing data from the nationwide FinACAF study, which included 13,781 patients with a mean age of 79.2 years, the results show significant differences i...

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Impact 3

Wrist-Measured Nighttime Home BP and Left Ventricular Hypertrophy: The WISDOM-HMOD Study.

Published: 2026-05-11

Hypertension (Dallas, Tex. : 1979)

MediLens Indexed: 2026-05-12

The WISDOM-HMOD study evaluated the relationship between nighttime blood pressure measured by a wrist-type monitor and left ventricular hypertrophy in 1218 patients with hypertension or heart failure. Results showed an average nighttime systolic/diastolic BP of 110.5±13.0/63.5±8.8 mm Hg, with 70....

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Impact 3

Gene Therapy for Cardiomyopathy: Tools, Targets, and Trials.

Published: 2026-05-11

Circulation. Heart failure

MediLens Indexed: 2026-05-12

This review addresses the significant advancements in cardiac gene therapy for cardiomyopathy, highlighting the transition of adeno-associated virus-mediated gene replacement into early-phase clinical trials. It notes improvements in biomarkers like NT-proBNP and discusses the challenges in deliv...

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Impact 3

Improved Cardiac Function and Glycemic Control in Elderly Diabetic Patients Through Structured Case Management After CABG.

Published: 2026-05-11

Medical science monitor : international medical journal of experimental and clinical research

MediLens Indexed: 2026-05-12

This study evaluated the impact of a structured, multidisciplinary case management model on cardiac function and glycemic control in elderly patients with coronary heart disease and diabetes undergoing off-pump CABG. A total of 168 patients were randomized to receive either routine care or an enh...

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Impact 3

Finerenone and Empagliflozin in Type 2 Diabetes.

Published: 2026-05-11

Cardiology in review

MediLens Indexed: 2026-05-12

This study highlights the critical role of sodium-glucose cotransporter 2 inhibitors and nonsteroidal mineralocorticoid receptor antagonists in reducing cardiovascular and kidney disease risks in patients with type 2 diabetes. Empagliflozin showed significant benefits in reducing cardiovascular m...

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Oncology5 articles

Impact 3

Mutations Targeted by Nous-209 Immunotherapy Occur Early in Lynch Syndrome Carriers' Precancer Lesions with Microsatellite Instability.

Published: 2026-05-11

Cancer prevention research (Philadelphia, Pa.)

MediLens Indexed: 2026-05-12

This study characterizes precancerous colorectal lesions in Lynch syndrome carriers and evaluates the potential of Nous-209 immunotherapy for cancer prevention. Among 50 adenomas and 12 advanced adenomas from 26 carriers, 83% of advanced adenomas and 58% of adenomas were found to be MMR-deficient...

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Impact 3

Multifunctionally Modified Low Molecular Weight PEI for Efficient Gene Delivery and Ferroptosis-Induced Antitumor Activity.

Published: 2026-05-11

Biomacromolecules

MediLens Indexed: 2026-05-12

This study presents a multifunctional cationic polymer (PFFc) designed for efficient gene delivery and induction of ferroptosis in cancer therapy. The polymer demonstrated strong gene-specific cytotoxicity in proliferation assays, outperforming nontherapeutic controls. Mechanistically, PFFc enhan...

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Impact 3

iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk.

Published: 2026-05-11

Signal transduction and targeted therapy

MediLens Indexed: 2026-05-12

The study presents iS2C2, a novel platform that integrates computational algorithms with large language models to analyze single-cell RNA-seq and spatial transcriptomics data. This platform addresses the limitations of traditional methods by generating biologically interpretable hypotheses. When ...

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Impact 3

Comparative Assessment of Free Energy Computational Methods for Revealing the Interactions Driving PARP1 Selective Inhibition.

Published: 2026-05-11

Journal of chemical information and modeling

MediLens Indexed: 2026-05-12

This study evaluates three computational methods for predicting inhibitor selectivity in PARP enzymes relevant to ovarian, breast, and prostate cancers. MM/PBSA provides qualitative insights but is sensitive to conformational changes, while ABFE and US methods yield better alignment with experime...

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Impact 2

Performance of multimodal large language models for the detection and characterization of bone lesions on radiographs.

Published: 2026-05-11

Diagnostic and interventional radiology (Ankara, Turkey)

MediLens Indexed: 2026-05-12

This study evaluated five large language models (LLMs) for detecting and characterizing bone lesions on plain radiographs using 3,746 images. ChatGPT 5.2 showed the best accuracy (0.803) and specificity (0.916) for lesion detection, while Claude Sonnet 4.6 and Gemini 3 Flash excelled in sensitivi...

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Neurology5 articles

Impact 3

Safety of Rapid Local Ischemic Postconditioning After Thrombectomy in Acute Stroke: A Dose-Finding Trial (RAPID SAVE).

Published: 2026-05-11

Stroke

MediLens Indexed: 2026-05-12

This study investigates the feasibility and safety of rapid local ischemic postconditioning after mechanical thrombectomy in acute ischemic stroke patients. Conducted as a multicenter phase I trial, it identified a 2/2 minutes×4 regimen as optimal, achieving a favorable efficacy-toxicity profile....

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Impact 3

RvD1/FPR2 attenuates cerebral ischemic injury through inhibiting inflammation and oxidative stress.

Published: 2026-05-11

Scientific reports

MediLens Indexed: 2026-05-12

This study explores the neuroprotective effects of resolvin D1 (RvD1) and its receptor FPR2 in a rat model of ischemic stroke. The results indicate that RvD1 treatment significantly reduces neurological deficits and infarct volume while decreasing neuronal apoptosis. Additionally, RvD1 modulates ...

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Impact 2

Acquired Idiopathic Generalized Anhidrosis as a Late-Onset Immune-Related Adverse Event of Pembrolizumab in a Patient With Lung Adenocarcinoma: A Case Report and Review of the Literature.

Published: 2026-05-11

The Journal of dermatology

MediLens Indexed: 2026-05-12

This case report describes a 69-year-old man with unresectable lung adenocarcinoma who developed acquired idiopathic generalized anhidrosis (AIGA) after 30 cycles of pembrolizumab. The patient exhibited significant anhidrosis and elevated serum carcinoembryonic antigen (CEA) levels, which prompte...

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Impact 2

Social and Environmental Determinants of Stroke Functional Outcome and Strategies to Reduce Inequities: A Scientific Statement From the American Heart Association.

Published: 2026-05-11

Stroke

MediLens Indexed: 2026-05-12

Stroke recovery is influenced by various social and environmental determinants beyond immediate medical treatment. This statement reviews these factors' effects on functional outcomes and secondary prevention strategies. It emphasizes the need for actionable strategies, including identifying upst...

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Impact 2

[Strengthening the prevention and control of visual impairment among children in China].

Published: 2026-05-11

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

MediLens Indexed: 2026-05-12

The paper discusses the high prevalence and complex causes of visual impairment among Chinese children, including conditions like refractive errors and amblyopia. It highlights that many impairments are preventable or curable but are hindered by limited public awareness and a fragmented service s...

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Gastroenterology5 articles

Impact 2

Gut microbiota-regulated glutathione metabolic rhythms restore obesity-induced colonic inflammatory oscillations.

Published: 2026-12-31

Gut microbes

MediLens Indexed: 2026-05-11

The study investigates the impact of obesity on circadian inflammatory rhythms, a key aspect of metabolic syndrome. It demonstrates that a high-fat diet disrupts microbiota-regulated glutathione metabolism, leading to altered colonic inflammatory rhythms. The use of fructo-oligosaccharide (FOS) a...

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Impact 2

Endoscopic grading of gastric intestinal metaplasia and microvascular pattern for assessing gastric cancer risk: a prospective study.

Published: 2026-12-01

Annals of medicine

MediLens Indexed: 2026-05-12

This study validates the diagnostic accuracy of the endoscopic grading of gastric intestinal metaplasia (EGGIM) for identifying high-risk gastric intestinal metaplasia (GIM) patients. A total of 144 patients were evaluated, revealing an area under the curve (AUC) of 0.885 for EGGIM in diagnosing ...

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Impact 3

Significant Intra-pancreatic Fat Deposition as an Independent Prognostic Factor in High-grade Pancreatic Neuroendocrine Neoplasms.

Published: 2026-05-11

Annals of surgical oncology

MediLens Indexed: 2026-05-12

This study evaluates the prognostic value of significant intra-pancreatic fat deposition (IPFD) in patients with high-grade pancreatic neuroendocrine neoplasms (panNENs). Among 87 patients, 27.6% exhibited significant IPFD, which was linked to worse overall and disease-specific survival outcomes....

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Impact 2

Advanced therapies for extraintestinal manifestations of IBD: a systematic review and meta-analysis.

Published: 2026-05-11

Inflammatory bowel diseases

MediLens Indexed: 2026-05-12

This systematic review evaluated the efficacy of advanced therapies for treating extraintestinal manifestations (EIMs) in inflammatory bowel diseases (IBDs). It included 49 studies, revealing that TNF antagonists and JAK inhibitors were effective for musculoskeletal EIMs, with response rates of 6...

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Impact 2

Real-world outcomes of pembrolizumab in advanced anal cancer: a nationwide Danish anal Cancer Group report.

Published: 2026-05-11

Acta oncologica (Stockholm, Sweden)

MediLens Indexed: 2026-05-12

This study investigates the effectiveness of pembrolizumab in treating advanced squamous cell carcinoma of the anal canal (SCCA) in a real-world cohort of 37 Danish patients. The objective response rate was 13.5%, with a clinical benefit rate of 48.6%. Median progression-free survival was 4.0 mon...

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Pulmonology5 articles

Impact 2

Exploiting the dynamics of hyperthermia-enhanced delivery of thermosensitive liposomal doxorubicin to solid tumors.

Published: 2026-12-31

Drug delivery

MediLens Indexed: 2026-05-12

This study investigates thermosensitive liposomal drug delivery for solid tumors, focusing on the impact of hyperthermia schedules on delivery efficacy. Using mathematical modeling, the research simulates the delivery of TSL-encapsulated doxorubicin (DOX) and calibrates the model against existing...

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Impact 2

Clinical significance of soluble E-selectin and soluble vascular cell adhesion molecule-1 levels in umbilical cord blood for neonatal respiratory distress syndrome: a retrospective study.

Published: 2026-12-01

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

MediLens Indexed: 2026-05-12

This study investigates the role of soluble E-selectin and soluble vascular cell adhesion molecule-1 in umbilical cord blood as biomarkers for neonatal respiratory distress syndrome (NRDS). In a cohort of 558 preterm infants, both markers were found to be elevated in NRDS cases and correlated wit...

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Impact 3

Community-acquired Pneumonia in Bangladeshi Children Under Five: Pathogen Prevalence, Resistance Trends, and Diagnostic Biomarkers.

Published: 2026-05-11

The Pediatric infectious disease journal

MediLens Indexed: 2026-05-12

This study investigates community-acquired pneumonia (CAP) in children under 5 years in Dhaka, Bangladesh, enrolling 226 cases and 201 controls. Key findings include significant associations of Streptococcus pneumoniae and respiratory syncytial virus with CAP, and a high prevalence of non-pneumoc...

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Impact 2

Pulmonary microbiota-associated formononetin modulates microglial activation in asthma-related anxiety.

Published: 2026-05-11

Journal of neuroinflammation

MediLens Indexed: 2026-05-12

This study explores the relationship between asthma and anxiety disorders, focusing on the role of pulmonary microbiota and its metabolites in anxiety-like behavior using a mouse model. The research identifies that certain asthmatic mice exhibit anxiety-like phenotypes linked to hippocampal neuro...

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Impact 2

A robust cell-based infection model for Rhinovirus C research and antiviral drug discovery.

Published: 2026-05-11

Npj viruses

MediLens Indexed: 2026-05-12

Rhinoviruses, particularly RV-C, are linked to severe respiratory illnesses, necessitating effective antiviral strategies. This study presents a high-content imaging-based high-throughput infection system for RV-C, utilizing a genetically stable fluorescent reporter virus. A screening of approxim...

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Endocrinology5 articles

Impact 2

Association between glycemic variability and composite adverse neonatal outcomes in patients with gestational diabetes mellitus: a retrospective study.

Published: 2026-12-01

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

MediLens Indexed: 2026-05-12

This study investigates the relationship between glycemic variability (GV) and adverse neonatal outcomes in women with gestational diabetes mellitus (GDM). A total of 160 women were analyzed, revealing that 41.88% experienced composite adverse neonatal outcomes (CANO). Those with CANO exhibited s...

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Impact 3

Risk factors for sudden cardiac death or sudden unexplained death in patients treated with clozapine: systematic review.

Published: 2026-05-11

BJPsych open

MediLens Indexed: 2026-05-12

This systematic review identifies risk factors for sudden cardiac death (SCD) and sudden unexplained death (SUD) in clozapine-treated patients. Analyzing 21 studies with 498 cases, it categorizes risk factors into treatment intensity, drug interactions, lifestyle factors, and monitoring. Notably,...

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Impact 3

Effects of pharmacological treatment and lifestyle modification on prediabetes: a systematic review and meta-analysis of randomized controlled trials (RCTS).

Published: 2026-05-11

Naunyn-Schmiedeberg's archives of pharmacology

MediLens Indexed: 2026-05-12

This meta-analysis highlights the effectiveness of pharmacological treatments combined with lifestyle modifications in reducing the incidence of diabetes and increasing the likelihood of achieving normoglycemia in prediabetic individuals. The analysis included randomized controlled trials and sho...

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Impact 2

Effectiveness of Continuous Glucose Monitoring on Glycemic and Metabolic Outcomes in Type 2 Diabetes: A Two-Year Real-World Analysis.

Published: 2026-05-11

Journal of diabetes science and technology

MediLens Indexed: 2026-05-12

This study evaluated the long-term effects of continuous glucose monitoring (CGM) on glycemic control and health care utilization in adults with type 2 diabetes (T2D). A retrospective chart review over two years included 222 adults, revealing that sustained CGM use led to significant improvements...

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Impact 2

Identifying classes with different disability profiles among patients undergoing lumbar discectomy: a latent class analysis.

Published: 2026-05-11

International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation

MediLens Indexed: 2026-05-12

This study analyzed 534 patients undergoing lumbar discectomy to identify distinct functional profiles using latent class analysis. Four classes of disability were found, with 30% experiencing severe disability. Factors such as female sex, obesity, older age, and greater pain severity were linked...

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Nephrology5 articles

Impact 3

Impact of pre-operative factors on post-operative atrial fibrillation outcomes after cardiac surgery: systematic review with meta-analysis, trial sequential analysis, and meta-regression.

Published: 2026-05-11

Acta cardiologica

MediLens Indexed: 2026-05-12

This systematic review and meta-analysis evaluated the association between post-operative atrial fibrillation (POAF) and adverse outcomes in cardiac surgery patients. Analyzing 54 studies involving 623,962 patients, the findings revealed that POAF significantly increases the risk of early mortali...

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Impact 3

Beyond binary AKI classification: development and external validation of a distributional model predicting serum creatinine and urine output trajectories in ICU patients.

Published: 2026-05-10

Critical care (London, England)

MediLens Indexed: 2026-05-12

This study presents a novel multi-step, multivariate distributional regression model for predicting acute kidney injury (AKI) in ICU patients. Developed from a training cohort of 4,118 ICU stays, the model was externally validated across four diverse cohorts, demonstrating a mean AUC-PR of 0.774,...

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Impact 2

Chrysin attenuates tramadol-driven renal dysfunction via regulation of RNA networks, antioxidant pathways, and ketogenic metabolism.

Published: 2026-05-10

European journal of pharmacology

MediLens Indexed: 2026-05-11

This study investigates the nephrotoxic effects of tramadol on renal function and the potential protective role of chrysin. The results show that tramadol significantly increases serum creatinine and BUN levels, as well as various renal damage biomarkers. Additionally, there are notable increases...

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Impact 1

Clinical Prediction Models for Acute Kidney Injury in Neonatology-A Systematic Review and Modelling Analysis.

Published: 2026-05-10

Journal of paediatrics and child health

MediLens Indexed: 2026-05-12

This study reviews clinical prediction rules (CPRs) for predicting acute kidney injury (AKI) in neonates within neonatal intensive care units (NICUs). A systematic search identified 685 articles, with three meeting inclusion criteria after full-text review. The sample sizes of these studies range...

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Impact 3

Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions.

Published: 2026-05-09

Molecular biomedicine

MediLens Indexed: 2026-05-11

This study emphasizes the role of acute kidney injury (AKI) as a significant contributor to chronic kidney disease (CKD) progression, highlighting the mechanisms involved, such as inadequate repair and persistent structural damage. It discusses the pathological processes, including cell cycle arr...

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Rheumatology5 articles

Impact 2

Reference ranges and influencing factors of pressure pain threshold in Chinese patients with knee osteoarthritis.

Published: 2026-12-01

Annals of medicine

MediLens Indexed: 2026-05-12

This study establishes preliminary pressure pain threshold (PPT) reference ranges for end-stage knee osteoarthritis (KOA) patients and healthy controls in Xi'an, China. A total of 165 KOA patients and 146 matched controls were assessed, revealing significantly lower median PPTs in KOA patients (f...

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Impact 2

Discovery, development, and characterization of SPY002 and SPY072, two novel extended half-life monoclonal antibodies targeting TL1A: in vitro properties, in vivo pharmacology, pharmacokinetics, and preclinical safety.

Published: 2026-12-01

mAbs

MediLens Indexed: 2026-05-11

This study investigates TL1A, a proinflammatory cytokine, and its role in immune-mediated diseases, particularly ulcerative colitis and Crohn's disease. The research focuses on two novel monoclonal antibodies, SPY002 and SPY072, which inhibit TL1A, detailing their binding affinity, specificity, a...

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Impact 2

T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives.

Published: 2026-05-11

Clinical reviews in allergy & immunology

MediLens Indexed: 2026-05-12

This review discusses the role of T-cell immunosenescence in systemic lupus erythematosus (SLE), highlighting its contribution to the disease's pathogenesis and complications. It proposes a vicious cycle of immunosenescence and inflammation, linking T-cell dysfunction to various comorbidities. Th...

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Impact 2

Musculoskeletal ultrasound for rheumatic diseases in low-resource settings: Current challenges and mitigating strategies.

Published: 2026-05-10

Tropical doctor

MediLens Indexed: 2026-05-12

This narrative review discusses the incorporation of musculoskeletal ultrasound (MSK-US) in rheumatology, highlighting its advantages over clinical examination and its cost-effectiveness compared to MRI. Despite its benefits, the adoption rate among rheumatologists is low. The review emphasizes t...

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Impact 2

Ethnopharmacological validation of Calotropis gigantea L. flower extract against rheumatoid arthritis: Anti-arthritic and immunomodulatory effects in a CFA-induced rat model.

Published: 2026-05-10

Journal of ethnopharmacology

MediLens Indexed: 2026-05-11

This study validates the traditional use of Calotropis gigantea for inflammatory joint disorders by demonstrating its anti-arthritic, antioxidant, and immunomodulatory effects in a rat model of rheumatoid arthritis. The ethanolic extract significantly reduced clinical signs of arthritis, improved...

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Infectious Disease5 articles

Impact 3

Population-level impact of HPV vaccination: a global systematic review of ecological, cross-sectional, and cohort studies.

Published: 2026-12-01

Expert review of vaccines

MediLens Indexed: 2026-05-12

This systematic review evaluates the impact of HPV vaccination on various HPV-related outcomes. The analysis included 63 studies, revealing significant declines in HPV infection (58-100%), CIN2+ (30-88%), genital warts (60-90%), and invasive cervical cancer (70-88%) in settings with high coverage...

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Impact 3

Screening of Sepsis Diagnostic Biomarkers Based on Fumarate Metabolism-Related Genes with Analysis of Immune Infiltration and Subtype Identification.

Published: 2026-05-11

Immunological investigations

MediLens Indexed: 2026-05-12

This study addresses the critical issue of sepsis by identifying four core diagnostic genes associated with fumarate metabolism (EPHX2, S100A8, TXN, ANXA3). It highlights significant immune microenvironment changes in sepsis patients, including increased neutrophil and M1 macrophage infiltration ...

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Impact 3

Epidemiology, resistance and virulence of neonatal Klebsiella pneumoniae isolates from a tertiary hospital in Tanzania.

Published: 2026-05-11

The Journal of infectious diseases

MediLens Indexed: 2026-05-12

This study investigates Klebsiella pneumoniae infections in neonates, revealing high rates of antibiotic resistance, particularly to penicillins and cephalosporins. The average birth weight of affected neonates was 2545.8 g, with significant resistance observed in 58.5% of isolates to ciprofloxac...

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Impact 2

Molecular detection of incidental Mycobacterium tuberculosis and nontuberculous mycobacteria co-detections using DNA strip assay: a laboratory-based study.

Published: 2026-05-11

Scientific reports

MediLens Indexed: 2026-05-12

This study evaluates the effectiveness of molecular methods for detecting Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacteria (NTM) in clinical samples. Analyzing 890 samples, it found that 27 (3.03%) were positive for NTM, with 19 (70.3%) showing only NTM and 8 (29.6%) showing MTB-...

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Impact 1

Speed is Not Enough: Disentangling Potential Baseline Optimized Antibiotic Stewardship and Temporal Spillover in Diagnostic Trials.

Published: 2026-05-11

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

MediLens Indexed: 2026-05-12

(No abstract provided)

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Hematology5 articles

Impact 2

The prognostic value of AQP1 in hyperbilirubinemia related to ABO hemolytic disease of the newborn.

Published: 2026-12-31

Hematology (Amsterdam, Netherlands)

MediLens Indexed: 2026-05-11

This study evaluates the prognostic value of Aquaporin 1 (AQP1) in neonates with ABO hemolytic disease of the newborn (ABO-HDN) and hyperbilirubinemia. A cohort of 168 neonates was analyzed, revealing that AQP1 levels were significantly elevated in affected infants compared to controls. The findi...

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Impact 3

DOCK1 inhibitor Box5 (TFA) suppresses proliferation of AML cell lines and prolongs survival in AML xenograft models.

Published: 2026-05-11

Scientific reports

MediLens Indexed: 2026-05-12

This study investigates the role of DOCK1 in acute myeloid leukemia (AML), identifying it as a prognostic biomarker with elevated expression predicting poor survival. The research demonstrates that targeting DOCK1 through a novel small-molecule inhibitor, Box5 (TFA), significantly reduces AML cel...

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Impact 3

Preliminary investigation into the association of serum free kappa light chains with risk stratification, clonal evolution and precision therapy in multiple myeloma.

Published: 2026-05-11

British journal of haematology

MediLens Indexed: 2026-05-12

This study highlights the clinical significance of abnormal serum free light chain (sFLC) κ in newly diagnosed multiple myeloma (NDMM). A retrospective analysis of 113 NDMM patients revealed that abnormal sFLC κ is associated with poor prognosis and lower rates of deep remission following VRd the...

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Impact 2

Impact of Tranexamic acid in reducing intra-operative blood loss during mono-polar TURP in geriatric population: a comparative study from Pakistan - a state highly prevalent of anemia.

Published: 2026-05-11

BMC urology

MediLens Indexed: 2026-05-12

In a study involving 60 elderly patients undergoing Transurethral Resection of the Prostate (TURP), the administration of a single 1 g dose of tranexamic acid (TXA) before anesthesia significantly reduced intra-operative blood loss compared to a control group. Blood loss was 289 ± 76 ml in the TX...

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Impact 2

Management of Iron Overload in Infants and Toddlers With Diamond-Blackfan Anemia Syndrome: A French-Italian Study.

Published: 2026-05-11

American journal of hematology

MediLens Indexed: 2026-05-12

This study investigates the management of iron overload in young patients with Diamond-Blackfan Anemia Syndrome (DBAS) requiring chronic transfusions. A retrospective analysis of 167 patients revealed that 38% began chelation therapy before age three, primarily using deferasirox. The therapy sign...

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Psychiatry5 articles

Impact 3

Cost-effectiveness analysis of xanomeline and trospium chloride for the treatment of adults with schizophrenia in the US.

Published: 2026-12-01

Journal of medical economics

MediLens Indexed: 2026-05-11

This study evaluates the cost-effectiveness of xanomeline and trospium chloride (KarXT) as a first line treatment for schizophrenia. Using a decision tree-Markov hybrid model, the analysis found that KarXT is more costly but also more effective than common generic antipsychotics, yielding favorab...

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Impact 2

Analyzing the direct medical cost of Schizophrenia in Hospital Pulau Pinang, Malaysia.

Published: 2026-05-11

Expert review of pharmacoeconomics & outcomes research

MediLens Indexed: 2026-05-12

This study evaluates the direct medical costs associated with schizophrenia (SCZ) at Hospital Pulau Pinang in Malaysia. A retrospective analysis of 120 adult patients revealed that the mean annual inpatient cost per patient was MYR 8,483.4, with hospitalization accounting for 62% of this cost. Ou...

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Impact 2

[Disordered eating behaviors and eating disorders among athletes].

Published: 2026-05-10

Orvosi hetilap

MediLens Indexed: 2026-05-12

This literature review examines the forms and consequences of disordered eating behaviors and eating disorders in athletic populations, highlighting their multifactorial origins. It discusses the significance of the female athlete triad and confirms the involvement of male athletes, particularly ...

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Impact 2

Motivational deficits and anhedonia in schizophrenia: insights from behavioral activation and behavioral inhibition systems.

Published: 2026-05-10

Annals of general psychiatry

MediLens Indexed: 2026-05-12

This study investigates the relationship between Behavioral Inhibition System (BIS) and Behavioral Activation System (BAS) activity, depressive symptoms, and anhedonia in schizophrenia. Involving 61 patients and 62 healthy controls, the findings indicate that reduced BAS activity in schizophrenia...

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Impact 2

Anxiety, Bipolar, Depressive, and Schizophrenia Diagnoses Among Patients Receiving Addiction Treatment in the United States, 2006-2022: A Descriptive Study.

Published: 2026-05-10

Substance use & addiction journal

MediLens Indexed: 2026-05-11

This study analyzed mental health diagnoses among patients in addiction treatment from 2006 to 2022, using Joinpoint regression on Treatment Episode Data Set - Admissions. The total sample included 224,051 patients, with 13% having anxiety disorders, 30.3% bipolar disorders, 43.4% depressive diso...

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Dermatology5 articles

Impact 2

Distinct ocular safety profiles of dupilumab and upadacitinib in atopic dermatitis: a real-world study with ophthalmological and microbiological assessment.

Published: 2026-12-01

The Journal of dermatological treatment

MediLens Indexed: 2026-05-10

This study compares ocular outcomes and conjunctival microbiology in patients with moderate-to-severe atopic dermatitis treated with dupilumab versus upadacitinib. The results indicate that while both treatments have comparable dermatological efficacy, dupilumab is linked to a higher incidence of...

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Impact 2

Sentinel lymph node detection in melanoma: indocyanine green fluorescence compared with conventional mapping techniques.

Published: 2026-05-11

Melanoma research

MediLens Indexed: 2026-05-12

This review evaluates the efficacy of near-infrared fluorescence with indocyanine green (ICG) compared to conventional sentinel lymph node (SLN) mapping techniques using technetium-99m (Tc-99m) and blue dye in melanoma staging. ICG demonstrates high identification rates (≈79-100%) and is superior...

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Impact 2

Novel uveal melanoma patient-derived cell line and organoid models show increased treatment resistance compared with commercially available cell lines.

Published: 2026-05-11

Melanoma research

MediLens Indexed: 2026-05-12

This study compares the drug responses of uveal melanoma patient-derived cell lines (PDLs) and patient-derived organoids (PDOs) with commercially available cell lines, contextualizing laboratory results with clinical trial outcomes. The results indicate that while commercial cell lines showed a v...

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Impact 1

Report From the International Conference on Incontinentia Pigmenti: Translating Discovery to Therapy.

Published: 2026-05-11

American journal of medical genetics. Part A

MediLens Indexed: 2026-05-12

Incontinentia pigmenti (IP) is a rare X-linked dominant condition with significant CNS and ophthalmic manifestations that can lead to neurologic impairment and vision loss. A conference was held to address the limited understanding of IP and to provide recommendations for screening and management...

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Impact 1

Spesolimab for Generalized Pustular Psoriasis in the Late Second Trimester of Pregnancy.

Published: 2026-05-11

The Journal of dermatology

MediLens Indexed: 2026-05-12

(No abstract provided)

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Ophthalmology5 articles

Impact 2

Global, Regional, and National Burden of Cataracts Attributable to Household Air Pollution from 1990 to 2021, with Projections to 2035.

Published: 2026-05-11

Ophthalmic epidemiology

MediLens Indexed: 2026-05-12

This study quantifies the cataract burden attributable to household air pollution (HAP) using data from the Global Burden of Disease database from 1990 to 2021. In 2021, the global HAP-attributable cataract burden was 1956.32 thousand years lived with disability (YLDs), with a rate of 22.84 per 1...

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Impact 2

[Progress in the development and application of disease-specific databases related to eye diseases].

Published: 2026-05-11

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

MediLens Indexed: 2026-05-12

This review discusses disease-specific databases as critical tools for clinical research in ophthalmology, focusing on their construction, classification, applications, and developmental trends. It synthesizes recent findings from both domestic and international studies and highlights high-qualit...

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Impact 2

Diabetic Retinopathy Outcomes and Early Worsening of Diabetic Retinopathy in Adolescents and Young Adults With Type 1 Diabetes Following Rapid and Large Glycemic Improvements After Commencing Automated Insulin Delivery.

Published: 2026-05-11

Journal of diabetes science and technology

MediLens Indexed: 2026-05-12

This study evaluated the outcomes of diabetic retinopathy in adolescents and young adults with type 1 diabetes following the initiation of automated insulin delivery (AID). It included 95 participants with a mean age of 17.8 years and a baseline HbA1c of 10.3%. After AID initiation, HbA1c improve...

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Impact 2

Integrin α2 Level is a Critical Determinant for Mesenchymal to Endothelial Phenotype Transition of Trabecular Meshwork Cells.

Published: 2026-05-10

Current eye research

MediLens Indexed: 2026-05-12

This study investigates the role of integrin α2 in trabecular meshwork (TM) cells, which are crucial for aqueous humor outflow regulation in glaucoma. The findings indicate that TGF-β2 reduces integrin α2 expression, leading to enhanced mesenchymal characteristics in TM cells. Conversely, the int...

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Impact 1

Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration.

Published: 2026-05-10

Genome medicine

MediLens Indexed: 2026-05-11

(No abstract provided)

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Pediatrics5 articles

Impact 2

Posaconazole therapeutic drug monitoring in pediatrics: a single-center retrospective study.

Published: 2026-05-11

BMC pediatrics

MediLens Indexed: 2026-05-12

This study assessed posaconazole therapeutic targets in immunosuppressed pediatric patients. It found that among 42 patients, the mean initial trough concentration was 1.4 ± 1.3 mg/L, with 59.5% achieving therapeutic levels. Adverse events occurred in 23.8% of patients. These findings highlight t...

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Impact 2

[Artificial intelligence in pediatric ophthalmology: applications and perspectives].

Published: 2026-05-11

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

MediLens Indexed: 2026-05-12

This paper addresses the critical link between pediatric visual health and cognitive development, highlighting the public health implications. It discusses the challenges faced in the application of AI technology in pediatric ophthalmology, including data scarcity and model limitations. The paper...

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Impact 1

[A case of goldenhar syndrome presenting with entropion].

Published: 2026-05-11

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

MediLens Indexed: 2026-05-12

A 6-year-old girl presented with increased tearing in the right eye and was diagnosed with Goldenhar syndrome after examination revealed entropion of the right lower eyelid and multiple associated anomalies, including hemifacial microsomia and facial nerve palsy. This case underscores the need fo...

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Impact 2

Clinical Model-Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients.

Published: 2026-05-10

Clinical pharmacology and therapeutics

MediLens Indexed: 2026-05-12

This article discusses the limitations of traditional dosing strategies in pediatrics, which often fail to account for individual patient variability. It presents the establishment of a model-informed precision dosing (MIPD) consultation service in a children's hospital, highlighting its feasibil...

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Impact 3

High prevalence of antimicrobial resistance mechanisms in a rural hospital in Ethiopia.

Published: 2026-05-09

Anales de pediatria

MediLens Indexed: 2026-05-12

This study assessed the prevalence of antimicrobial resistance (AMR) genes in stool samples from 40 pediatric inpatients at a rural hospital in Ethiopia. Results showed that 82.5% of patients carried AMR genes, with CTX-M being the most common resistance mechanism (80.0%). The findings highlight ...

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Emergency Medicine5 articles

Impact 3

Early prognostication of septic shock in Korean adults aged 80 years and over: serum albumin combined with Sequential Organ Failure Assessment Score.

Published: 2026-05-11

Acute and critical care

MediLens Indexed: 2026-05-12

This study evaluated the combination of serum albumin levels and the SOFA score for risk stratification in patients aged 80 and over with septic shock. Conducted from October 2015 to May 2022, it included 1,300 patients. The results showed significant differences in 28-day mortality rates among t...

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Impact 2

The Impact of Blood Pressure Targets on Hemodynamics in Patients With Cardiogenic shock Caused by Infarction-Related Out-of-Hospital Cardiac Arrest: A Substudy of the BOX-trial.

Published: 2026-05-11

European heart journal. Acute cardiovascular care

MediLens Indexed: 2026-05-12

The BOX-trial subanalysis evaluated the effects of different noradrenaline-mediated MAP-targets on hemodynamics and outcomes in patients with cardiogenic shock due to OHCA. A total of 258 patients were analyzed, showing that while higher MAP-targets increased cardiac index and SvO2, they did not ...

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Impact 2

[The care of patients after hazardous materials incidents].

Published: 2026-05-11

Nederlands tijdschrift voor geneeskunde

MediLens Indexed: 2026-05-12

In HazMat incidents, rapid action is vital to prevent exposure and ensure proper care. Distinguishing between exposure and contamination is essential, as decontamination is only necessary when hazardous substances are on the patient's skin, hair, or clothing. Evidence indicates that the risk of s...

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Impact 2

Inferior Vena Cava to Aorta Ratio in Children With Non-Hemorrhagic Shock After Fluid Bolus Using Point of Care Ultrasound.

Published: 2026-05-11

Pediatric emergency care

MediLens Indexed: 2026-05-12

This study evaluates the IVC/Ao ratio and IVC collapsibility/distensibility indices in children aged 1 to 12 years with non-hemorrhagic shock before and after fluid bolus therapy. Significant increases in the IVC/Ao ratio and decreases in IVC indices were observed post-therapy. However, the weak ...

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Impact 2

An Estimate of Civilian Readiness Requirements for Surgeons: A Survey of American College of Surgeons Trauma Medical Directors.

Published: 2026-05-11

Military medicine

MediLens Indexed: 2026-05-12

This study evaluates the trauma call eligibility requirements set by civilian Trauma Medical Directors (TMDs) compared to military standards. A survey of 89 TMDs revealed that over 93% require monthly trauma shifts for eligibility, with significant percentages also mandating yearly trauma resusci...

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Surgery5 articles

Impact 3

Second stage labour duration and pelvic floor outcomes in primiparous women delivering macrosomic foetuses: a prospective study.

Published: 2026-12-01

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

MediLens Indexed: 2026-05-12

This study examines the impact of prolonged second stage of labour on pelvic floor dysfunction in first-time mothers delivering large babies. It involved 200 women stratified by pushing duration and assessed for pelvic floor health six weeks postpartum. Results indicated that those who pushed for...

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Impact 2

Leg positioner improves efficiency on selected steps in robotic-assisted total knee arthroplasty: an analysis of surgical workflow efficiency and team experience.

Published: 2026-12-01

Computer assisted surgery (Abingdon, England)

MediLens Indexed: 2026-05-10

This study investigates the impact of leg positioners on surgical efficiency in robotic-assisted total knee arthroplasty (TKA). A total of 79 procedures were analyzed, with 72% using leg positioners. The median cut-to-suture time was 1:29 hours, showing no significant difference between cases wit...

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Impact 3

Inguinal and Ventral Hernia Repair with the Hugo Robotic-Assisted Surgery System: A Prospective, Single-arm, Clinical Trial.

Published: 2026-05-11

Annals of surgery

MediLens Indexed: 2026-05-12

The study evaluated the safety and efficacy of the Hugo robotic-assisted surgery (RAS) platform for inguinal and ventral hernia repairs. In a prospective, multi-center trial involving 206 patients, the surgical success rate was 100%, with no conversions to other surgical methods. The rates of sur...

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Impact 2

A Fully Biological Gas-Exchange Membrane toward a Biofabricated, Booster Lung.

Published: 2026-05-11

ACS biomaterials science & engineering

MediLens Indexed: 2026-05-12

This study addresses the need for long-term respiratory support for chronic lung disease patients. It focuses on engineering a biological tissue that mimics the alveolar-capillary barrier for use in an implantable support lung. The collagen membranes created were 18.8 ± 3.6 μm thick, demonstrated...

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Impact 2

Minimally invasive surgery in the correction of recurrent hallux valgus: a case series with 2‑year follow‑up.

Published: 2026-05-11

BMC musculoskeletal disorders

MediLens Indexed: 2026-05-12

This study evaluated the outcomes of minimally invasive surgery for revision of recurrent hallux valgus in 33 patients. Both the MICA and META techniques showed significant improvements in angular correction and patient-reported outcomes, including pain and function, with low complication rates. ...

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Obstetrics & Gynecology5 articles

Impact 2

Forecasting preterm birth in Kazakhstan through 2050: a cohort-component demographic modeling study.

Published: 2026-12-31

Global health action

MediLens Indexed: 2026-05-10

This study estimates long-term trends in preterm birth in Kazakhstan through 2050 using demographic modeling. Analysis of national data from 2009 to 2023 revealed that annual preterm births ranged from about 21,000 to 27,000 between 2013 and 2023, with projections indicating stabilization at 30,0...

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Impact 2

Association of regional fat distribution indicators with infertility in women: insights from the 2013-2018 NHANES.

Published: 2026-12-31

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

MediLens Indexed: 2026-05-10

This study investigates the relationship between fat distribution and female infertility using NHANES data from 2,531 women aged 20-45. It finds that total percent fat, android percent fat, android fat/gynoid fat ratio, and body mass index are modestly associated with increased odds of infertilit...

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Impact 2

Postpartum care utilization among high-risk pregnancies in an urban safety-net health system.

Published: 2026-12-01

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

MediLens Indexed: 2026-05-12

This study evaluated postpartum and acute care utilization among individuals with high-risk pregnancies compared to low-risk pregnancies in an urban safety-net health system. A retrospective cohort study included 13,874 individuals, revealing that 68.0% had high-risk diagnoses. High-risk individu...

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Impact 2

Prenatal cigarette smoke exposure increases vulnerability to chronic retinal hypoperfusion in adult rats.

Published: 2026-12-01

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

MediLens Indexed: 2026-05-08

This study investigates the long-term effects of prenatal smoke exposure on retinal structure and vulnerability in adult rats. Wistar rats were exposed to tobacco smoke during pregnancy, and subsequent retinal analysis revealed significant reductions in retinal layer thickness and cell counts in ...

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Impact 2

Paeonol alleviates intrauterine adhesion by suppressing endometrial stromal cell activation via AKT1, based on network pharmacology.

Published: 2026-05-11

Reproduction, fertility, and development

MediLens Indexed: 2026-05-12

This study investigates the role of paeonol in treating intrauterine adhesion (IUA), a condition linked to secondary infertility and recurrent miscarriage. Using network pharmacology, the research identifies the molecular mechanisms through which paeonol operates, particularly its interaction wit...

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