循環器内科5 件

重要度 3

Evolving Strategies in Cardiac Amyloidosis: From Mechanistic Discoveries to Diagnostic and Therapeutic Advances.

論文発表日: 2026-04-01

Heart failure clinics

MediLens 収録日: 2026-04-02

心筋アミロイドーシスの診断と治療は、過去10年間で大きく進展し、病気の病因に焦点が当てられています。非侵襲的画像診断により、ATTR心筋症の診断が向上し、タンパク質安定化剤や遺伝子編集を含む新しい治療法がATTR-CMのために登場しました。AL-CMに対しては、化学療法と潜在的な自家幹細胞移植が治療に含まれます。これらの進展は、心筋アミロイドーシスにおける患者さんの転帰を改善することを目的としています。

医学研究トレンド

循環器内科5 件

Evolving Strategies in Cardiac Amyloidosis: From Mechanistic Discoveries to Diagnostic and Therapeutic Advances.

Surgical Site Infection in Coronary Artery Bypass: Observational Study.

Bundled Care Interventions for the Management of Intracerebral Hemorrhage: A Review.

Association of insomnia and its proteomic signatures with incident heart failure: A European population-based study.

Decreased AMP-kinase function in pulmonary artery smooth muscle cells contributes to pulmonary artery remodeling in persistent pulmonary hypertension of the newborn.

腫瘍内科1 件

Bridging mechanism and clinic: unlocking the full potential of oncolytic virus-based immunotherapy.

神経内科1 件

Retraction Note: An intelligent learning system based on electronic health records for unbiased stroke prediction.

消化器内科5 件

Bifunctional nanoparticles based on esterified hydroxypropyl β-cyclodextrin/quaternary ammonium chitosan for ulcerative colitis intervention.

Exploration of a Model for Elimination of Hepatitis C in Women of Childbearing Age in Primary Hospitals in Southern China.

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study.

Novel Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Induce ROS-Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2.

Phytogalactolipids triggered oxidative stress to inhibit drug-resistant colorectal cancer by suppressing interferon-α-induced protein 6.

呼吸器内科5 件

Upfront treatment with osimertinib in lung cancer patients with and without active brain metastases, and the role of ctDNA as a biomarker; a phase II clinical trial (the FIOL study).

Overall survival for amivantamab plus lazertinib versus osimertinib as first-line treatment in Asian participants with EGFR-mutant advanced NSCLC: A MARIPOSA subset analysis.

Defining response-adapted surgery after neoadjuvant systemic therapy in sinonasal squamous cell carcinoma.

Xbp1-driven lipid metabolism promotes immunosuppression in lung cancer: Jianpi Chutan Jiedu formula reshapes metabolic-immune crosstalk.

Pediatric Invasive Group A Streptococcus Infections with Central Nervous System Involvement: A Single Institution Case Series in Southern New England.

糖尿病・内分泌内科5 件

Development and Validation of Prognostic Models in Patients With Stage IV Thyroid Cancer Undergoing Surgical Treatment.

Clinical stage IIA/B embryonal carcinoma predominant nonseminomatous germ cell tumor: Minimizing treatment burden.

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas.

USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake.

腎臓内科5 件

Elevated triglyceride-glucose index is associated with increased risk of chronic kidney disease and end-stage renal disease in type 1 diabetes: Nationwide cohort study.

Ceftriaxone administration reduces vascular calcification associated with experimental models of chronic kidney disease.

Node Positive Resected Renal Cell Carcinoma Portends a Poor Prognosis: Results From the Canadian Kidney Cancer Collaboration.

Quality of Life After Abdominal Wall Reconstruction and the Establishment of a Pathway for Renal Transplant Recipients.

Minimizing radiation exposure in pediatric nephrolithiasis: The effectiveness of a low-dose computed tomography protocol.

リウマチ・膠原病内科3 件

Incidence of Surgery for Pediatric Wrist Ganglion Cysts.

Certolizumab pegol, abatacept, tocilizumab or active conventional therapy in early rheumatoid arthritis: 48-week patient-reported outcomes from the NORD-STAR trial.

Outcomes and Complications of Suture-Button versus All-Suture Suspensionplasty in Thumb Carpometacarpal Arthritis: A Retrospective Comparative Study.

感染症内科1 件

An Unusual Cause of Massive Gastrointestinal Bleed in a Girl with Abdominal Tuberculosis.

血液内科5 件

Bronchiolitis Obliterans or Busulfan-Induced Lung Injury? A Pediatric Case of Hematopoietic Stem Cell Transplantation.

Eosinophilic, polymorphic, and pruritic eruption associated with radiation treated with dupilumab in a patient with Hodgkin lymphoma.

Bridging therapy before CAR-T for multiple myeloma: a survey from the CMWP and CTIWP of the EBMT.

Successful Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in X-Linked Sideroblastic Anemia.

HSR26-237: Meta-Analysis Confirms Venetoclax Plus Decitabine as a Frontline Game-Changer in Elderly AML (Acute Myeloid Leukemia).

精神科1 件

Correction to "Clinical and Societal Burden of Incident Major Depressive Disorder: A Population-Wide Cohort Study in Stockholm".

皮膚科5 件

On the role of cholesterol, vitamin D, lumisterol, and tachysterol signaling in psoriasis.

Successful use of spesolimab in refractory pyoderma gangrenosum.

Response to Brenaut et al., "Response to Pham et al's 'Sensory symptoms of scalp psoriasis are not sensitive scalp syndrome'".

Adults with a history of melanoma have higher odds of laryngeal cancer in the United States.

Folate-functionalized core-shell nanocarrier System for sustained and targeted delivery of

眼科3 件

Association between PCSK9 inhibitor use and risk of age-related macular degeneration.

Comment on: CATALYZE: a deep learning approach for cataract assessment and grading on SS-OCT images.

Comment on: ``Development and Evaluation of an Artificial Intelligence Model to Set Target IOP for Glaucoma''.

小児科2 件

Evaluation of PCORnet as an Approach to Accessing Electronic Health Record (EHR) Data for Cleft Outcomes Research: Advantages and Limitations.

Toxic epidermal necrolysis in a preschooler associated with adenovirus respiratory infection: A case report.

救急医学3 件

Intravenous Access Should Be Prioritized Over Intraosseous Access in Cardiac Arrest.

"Perioperative use of factor concentrates and blood products: a survey of clinical practices in the United States: communication from the ISTH Subcommittee on Perioperative and Critical Care": comment from Erdoes et al.

Ketamine Versus Etomidate in Rapid Sequence Intubation: What Difference Would Convince You?: April 2026 Annals of Emergency Medicine Journal Club.

外科5 件

Intrapericardial congenital diaphragmatic hernia: three-dimensional reconstruction.

Displaced kidneys in a giant inguinoscrotal hernia: an unusual cause of hydronephrosis.

Local infiltration of liposomal bupivacaine is associated with reduced postoperative admission in anterior abdominal hernia repair.

Incisional hernia repair using component separation with perforator preservation and onlay mesh: A pilot study.

Effect of mesh plane on short-term surgical and functional outcomes in ventral hernia repair with associated rectus diastasis.

産婦人科5 件

How She Was Born.

Enhancing diversity in endometriosis clinical trials: Application of the clinical diversity scoring framework.

Robotic-assisted transumbilical single-site and transvaginal NOTES resection of abdominal wall cesarean scar endometriosis: Two case reports.

Prenatal Diagnosis of Spinal Muscular Atrophy Facilitates Ultrarapid Treatment After Birth.

Polypoid Endometriosis Mimicking Peritoneal Carcinomatosis.

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