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Tendances de la Recherche Médicale

Les publications les plus percutantes de la semaine dans 29 spécialités, sélectionnées par IA

Dernière mise à jour: 1 avr. 2026

Endocrinologie5 articles

Impact 3

Development and Validation of Prognostic Models in Patients With Stage IV Thyroid Cancer Undergoing Surgical Treatment.

Publié: 2026-04-01

The American surgeon

MediLens Indexé: 2026-04-02

This study addresses the low survival rates in advanced thyroid cancer by developing a prognostic prediction model based on a cohort of 670 patients from the SEER database. Using univariate and multivariate Cox regression analyses, significant independent risk factors were identified, including g...

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Impact 3

Clinical stage IIA/B embryonal carcinoma predominant nonseminomatous germ cell tumor: Minimizing treatment burden.

Publié: 2026-04-01

Urologic oncology

MediLens Indexé: 2026-04-02

This study investigates the treatment burden of primary retroperitoneal lymph node dissection (RPLND) versus chemotherapy in patients with embryonal carcinoma predominance in nonseminomatous germ cell tumors. Among 126 patients, primary RPLND achieved a 3-year recurrence-free survival of 85.1%, w...

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Impact 3

Immunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.

Publié: 2026-04-01

Archives of endocrinology and metabolism

MediLens Indexé: 2026-04-02

This case report discusses a 71-year-old woman with poorly differentiated thyroid carcinoma (PDTC) who was ineligible for standard treatments. Molecular profiling indicated a high tumor mutational burden (TMB) and specific somatic mutations. The patient was treated with pembrolizumab, resulting i...

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Impact 3

NR3C1 Modulates Wnt Signalling to Influence the Invasiveness and Immune Features of Nonfunctioning Invasive Pituitary Adenomas.

Publié: 2026-04-01

Journal of cellular and molecular medicine

MediLens Indexé: 2026-04-02

This study investigates the role of NR3C1 in the invasiveness of nonfunctioning invasive pituitary adenomas (NIPAs). Using RNA-seq and mass spectrometry, the researchers identified NR3C1 as significantly upregulated in NIPAs, with strong discriminatory power in ROC analysis. Functional experiment...

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Impact 3

USP20-RAB8A signaling axis restricts pancreatic cancer progression by disrupting GLUT1 vesicular trafficking and inhibiting glucose uptake.

Publié: 2026-04-01

Cancer letters

MediLens Indexé: 2026-04-02

This study identifies a novel mechanism regulating glucose transporter 1 (GLUT1) in pancreatic ductal adenocarcinoma (PDAC) cells through RAB8A-dependent vesicular trafficking. RAB8A enhances GLUT1 localization to the membrane, increasing glucose uptake, while ubiquitin-specific peptidase 20 (USP...

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