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Tendencias en Investigación Médica

Las publicaciones de mayor impacto de la semana en 29 especialidades, seleccionadas por IA

Última actualización: 11 may 2026

Gastroenterología5 artículos

Impacto 2

Gut microbiota-regulated glutathione metabolic rhythms restore obesity-induced colonic inflammatory oscillations.

Publicado: 2026-12-31

Gut microbes

MediLens Indexado: 2026-05-11

The study investigates the impact of obesity on circadian inflammatory rhythms, a key aspect of metabolic syndrome. It demonstrates that a high-fat diet disrupts microbiota-regulated glutathione metabolism, leading to altered colonic inflammatory rhythms. The use of fructo-oligosaccharide (FOS) a...

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Impacto 2

Endoscopic grading of gastric intestinal metaplasia and microvascular pattern for assessing gastric cancer risk: a prospective study.

Publicado: 2026-12-01

Annals of medicine

MediLens Indexado: 2026-05-12

This study validates the diagnostic accuracy of the endoscopic grading of gastric intestinal metaplasia (EGGIM) for identifying high-risk gastric intestinal metaplasia (GIM) patients. A total of 144 patients were evaluated, revealing an area under the curve (AUC) of 0.885 for EGGIM in diagnosing ...

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Impacto 3

Significant Intra-pancreatic Fat Deposition as an Independent Prognostic Factor in High-grade Pancreatic Neuroendocrine Neoplasms.

Publicado: 2026-05-11

Annals of surgical oncology

MediLens Indexado: 2026-05-12

This study evaluates the prognostic value of significant intra-pancreatic fat deposition (IPFD) in patients with high-grade pancreatic neuroendocrine neoplasms (panNENs). Among 87 patients, 27.6% exhibited significant IPFD, which was linked to worse overall and disease-specific survival outcomes....

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Impacto 2

Advanced therapies for extraintestinal manifestations of IBD: a systematic review and meta-analysis.

Publicado: 2026-05-11

Inflammatory bowel diseases

MediLens Indexado: 2026-05-12

This systematic review evaluated the efficacy of advanced therapies for treating extraintestinal manifestations (EIMs) in inflammatory bowel diseases (IBDs). It included 49 studies, revealing that TNF antagonists and JAK inhibitors were effective for musculoskeletal EIMs, with response rates of 6...

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Impacto 2

Real-world outcomes of pembrolizumab in advanced anal cancer: a nationwide Danish anal Cancer Group report.

Publicado: 2026-05-11

Acta oncologica (Stockholm, Sweden)

MediLens Indexado: 2026-05-12

This study investigates the effectiveness of pembrolizumab in treating advanced squamous cell carcinoma of the anal canal (SCCA) in a real-world cohort of 37 Danish patients. The objective response rate was 13.5%, with a clinical benefit rate of 48.6%. Median progression-free survival was 4.0 mon...

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