Rheumatology5 articles

Impact 2

Reference ranges and influencing factors of pressure pain threshold in Chinese patients with knee osteoarthritis.

Published: 2026-12-01

Annals of medicine

MediLens Indexed: 2026-05-12

This study establishes preliminary pressure pain threshold (PPT) reference ranges for end-stage knee osteoarthritis (KOA) patients and healthy controls in Xi'an, China. A total of 165 KOA patients and 146 matched controls were assessed, revealing significantly lower median PPTs in KOA patients (f...

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Impact 2

Discovery, development, and characterization of SPY002 and SPY072, two novel extended half-life monoclonal antibodies targeting TL1A: in vitro properties, in vivo pharmacology, pharmacokinetics, and preclinical safety.

Published: 2026-12-01

mAbs

MediLens Indexed: 2026-05-11

This study investigates TL1A, a proinflammatory cytokine, and its role in immune-mediated diseases, particularly ulcerative colitis and Crohn's disease. The research focuses on two novel monoclonal antibodies, SPY002 and SPY072, which inhibit TL1A, detailing their binding affinity, specificity, a...

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Impact 2

T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives.

Published: 2026-05-11

Clinical reviews in allergy & immunology

MediLens Indexed: 2026-05-12

This review discusses the role of T-cell immunosenescence in systemic lupus erythematosus (SLE), highlighting its contribution to the disease's pathogenesis and complications. It proposes a vicious cycle of immunosenescence and inflammation, linking T-cell dysfunction to various comorbidities. Th...

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Impact 2

Musculoskeletal ultrasound for rheumatic diseases in low-resource settings: Current challenges and mitigating strategies.

Published: 2026-05-10

Tropical doctor

MediLens Indexed: 2026-05-12

This narrative review discusses the incorporation of musculoskeletal ultrasound (MSK-US) in rheumatology, highlighting its advantages over clinical examination and its cost-effectiveness compared to MRI. Despite its benefits, the adoption rate among rheumatologists is low. The review emphasizes t...

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Impact 2

Ethnopharmacological validation of Calotropis gigantea L. flower extract against rheumatoid arthritis: Anti-arthritic and immunomodulatory effects in a CFA-induced rat model.

Published: 2026-05-10

Journal of ethnopharmacology

MediLens Indexed: 2026-05-11

This study validates the traditional use of Calotropis gigantea for inflammatory joint disorders by demonstrating its anti-arthritic, antioxidant, and immunomodulatory effects in a rat model of rheumatoid arthritis. The ethanolic extract significantly reduced clinical signs of arthritis, improved...

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Medical Research Trends

Rheumatology5 articles

Reference ranges and influencing factors of pressure pain threshold in Chinese patients with knee osteoarthritis.

Discovery, development, and characterization of SPY002 and SPY072, two novel extended half-life monoclonal antibodies targeting TL1A: in vitro properties, in vivo pharmacology, pharmacokinetics, and preclinical safety.

T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives.

Musculoskeletal ultrasound for rheumatic diseases in low-resource settings: Current challenges and mitigating strategies.

Ethnopharmacological validation of Calotropis gigantea L. flower extract against rheumatoid arthritis: Anti-arthritic and immunomodulatory effects in a CFA-induced rat model.

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