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This week's highest-impact publications across 29 specialties, curated by AI

Last updated: May 22, 2026

Nephrology5 articles

Impact 2

Metabolic memory in the kidney: how lactate and lactylation drive the path from acute injury to chronic disease.

Published: 2026-12-01

Renal failure

MediLens Indexed: 2026-05-22

This review discusses the role of lactate and lysine lactylation in the progression from acute kidney injury to chronic kidney disease. It identifies four maladaptive repair processes involved: mitochondrial dysfunction, metabolic reprogramming, inflammation, and fibrosis. Lactylation is emphasiz...

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Impact 2

Computed tomography-measured trabecular attenuation at first lumbar vertebra as a surrogate marker of bone mineral density and osteoporosis in patients undergoing hemodialysis.

Published: 2026-12-01

Renal failure

MediLens Indexed: 2026-05-22

This study investigates the association between trabecular attenuation measured by CT at the first lumbar vertebra and bone mineral density (BMD) in Japanese patients on hemodialysis. The research included 119 patients, revealing a higher risk of fractures and osteoporosis in this population comp...

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Impact 2

Correlation of foot process effacement with clinicopathological features and short-term prognosis in IgA nephropathy.

Published: 2026-12-01

Annals of medicine

MediLens Indexed: 2026-05-22

This study investigates the impact of foot process effacement (FPE) severity on renal outcomes in patients with IgA nephropathy (IgAN). In a cohort of 1,001 patients, those with severe FPE exhibited significantly worse short-term outcomes, including lower complete remission rates compared to thos...

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Impact 2

Roxadustat attenuates contrast-induced acute kidney injury potentially mediated via the Nrf2/HO-1 signaling pathway.

Published: 2026-12-01

Renal failure

MediLens Indexed: 2026-05-22

This study investigates the protective effects of roxadustat on contrast-induced acute kidney injury (CI-AKI) in a mouse model. The findings indicate that roxadustat significantly mitigates the decline in antioxidant enzyme activity and reduces markers of oxidative stress and inflammation. Additi...

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Impact 2

Diagnostic challenge of postrenal transplant polyomavirus nephropathy with varied presentations: a case series.

Published: 2026-05-22

Clinical transplantation and research

MediLens Indexed: 2026-05-23

This study presents four unusual cases of polyomavirus nephropathy (PVN) in renal transplant recipients, highlighting the varied clinical and histopathological presentations of PVN. The cases include a 21-year-old woman with PVN and recurrent immunoglobulin A nephropathy, a 30-year-old man with P...

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