Notfallmedizin5 Artikel

Impact 2

Preclinical safety evaluation of the dipeptidyl peptidase 3 inhibiting antibody Procizumab in rodents and non-human primates.

Veröffentlicht: 2026-12-01

mAbs

MediLens Indexiert: 2026-05-23

This study investigates the safety and tolerability of Procizumab (PCZ), an antibody that antagonizes circulating dipeptidyl peptidase 3 (cDPP3), which is released during cellular stress and impacts vascular tone. The findings may have implications for resuscitation strategies in shock management.

Auf PubMed lesen

Impact 2

Safety, tolerability, and pharmacokinetics/-dynamics of the dipeptidyl peptidase 3-inhibiting antibody Procizumab in a first-in-human trial.

Veröffentlicht: 2026-12-01

mAbs

MediLens Indexiert: 2026-05-23

This study evaluates Procizumab (PCZ), a monoclonal antibody inhibiting DPP3, in a Phase 1 trial involving 24 healthy male volunteers. The background highlights DPP3's role in hemodynamic instability during cardiogenic shock. Preclinical models show that PCZ enhances angiotensin levels and improv...

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Impact 3

Novel Extracorporeal Life Support System to Mitigate Ischemia-Reperfusion Injury During Prolonged Aortic and Inferior Vena Caval Occlusion.

Veröffentlicht: 2026-05-22

ASAIO journal (American Society for Artificial Internal Organs : 1992)

MediLens Indexiert: 2026-05-23

This study investigates the use of an integrated ECMO and REBOA system in a porcine model to manage hemodynamics during high-risk abdominal surgeries. The findings demonstrate that the ECMO group had significantly improved survival rates, lactate clearance, and reduced norepinephrine requirements...

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Impact 2

Characteristics and outcomes of younger adults with out-of-hospital cardiac arrest resuscitated with extracorporeal membrane oxygenation: a nationwide study.

Veröffentlicht: 2026-05-22

BMC cardiovascular disorders

MediLens Indexiert: 2026-05-23

This study investigates the outcomes of younger adults (≤ 40 years) receiving extracorporeal cardiopulmonary resuscitation (ECPR) compared to older adults (> 40 years) in out-of-hospital cardiac arrest cases. It analyzes data from 2,129 patients, revealing that younger adults have fewer acute cor...

Auf PubMed lesen

Impact 2

The implementation of a national registry for international medical volunteers during armed conflict: the Israeli experience.

Veröffentlicht: 2026-05-22

Israel journal of health policy research

MediLens Indexiert: 2026-05-23

The Medical Volunteers for Israel (MVFI) registry was established to efficiently recruit and integrate international physicians into Israel's healthcare system during emergencies. An analysis of the registry from October 2023 to August 2025 revealed that 7,032 physicians were enrolled, with signi...

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Medizinische Forschungstrends

Notfallmedizin5 Artikel

Preclinical safety evaluation of the dipeptidyl peptidase 3 inhibiting antibody Procizumab in rodents and non-human primates.

Safety, tolerability, and pharmacokinetics/-dynamics of the dipeptidyl peptidase 3-inhibiting antibody Procizumab in a first-in-human trial.

Novel Extracorporeal Life Support System to Mitigate Ischemia-Reperfusion Injury During Prolonged Aortic and Inferior Vena Caval Occlusion.

Characteristics and outcomes of younger adults with out-of-hospital cardiac arrest resuscitated with extracorporeal membrane oxygenation: a nationwide study.

The implementation of a national registry for international medical volunteers during armed conflict: the Israeli experience.

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